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Mouse Anti-METTL21A Recombinant Antibody (CBXF-2525) (CBMAB-F1143-CQ)

This product is a mouse antibody that recognizes METTL21A. The antibody CBXF-2525 can be used for immunoassay techniques such as: WB, IF.
See all METTL21A antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXF-2525
Antibody Isotype
IgG2b
Application
WB, IF

Basic Information

Immunogen
Full length human recombinant protein of human FAM119A (NP_660323)
Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.3, 1% BSA, 50% glycerol
Preservative
0.02% sodium azide
Concentration
0.91 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
METTL21A
Introduction
METTL21A (Methyltransferase Like 21A) is a Protein Coding gene. Among its related pathways are Metabolism of proteins and Protein methylation. Gene Ontology (GO) annotations related to this gene include methyltransferase activity and Hsp70 protein binding. An important paralog of this gene is EEF1AKMT3.
Entrez Gene ID
151194
UniProt ID
Q8WXB1
Alternative Names
Methyltransferase Like 21A; Hepatocellular Carcinoma-Associated Antigen 557b; Heat Shock Protein 70kDa Lysine (K) Methyltransferase; Family With Sequence Similarity 119, Member A; Methyltransferase-Like Protein 21A; HSPA Lysine Methyltransferase;
Function
S-adenosyl-L-methionine-dependent methyltransferase that mediates N3-methylcytidine modification of residue 32 of the tRNA anticodon loop of tRNA(Thr)(UGU) and tRNA(Arg)(CCU) (PubMed:28655767, PubMed:34268557).

N3-methylcytidine methylation by METTL2A requires the N6-threonylcarbamoylation of tRNA (t6A37) by the EKC/KEOPS complex as prerequisite (PubMed:34268557).
Biological Process
tRNA methylation Source: UniProtKB
Cellular Location
Cytoplasm
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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