Mouse Anti-METTL21A Recombinant Antibody (2G7) (CBMAB-F0091-CQ)

Name: Mouse Anti-METTL21A Recombinant Antibody (2G7)
SKU: CBMAB-F0091-CQ
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

2G7

Application

WB, FC, IHC, IHC-P

Immunogen

Full length human recombinant protein of human FAM119A (NP_660323)

Specificity

Human

Antibody Isotype

IgG2b

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

METTL21A

Introduction

METTL21A (Methyltransferase Like 21A) is a Protein Coding gene. Among its related pathways are Metabolism of proteins and Protein methylation. Gene Ontology (GO) annotations related to this gene include methyltransferase activity and Hsp70 protein binding. An important paralog of this gene is EEF1AKMT3.

Entrez Gene ID

151194

UniProt ID

Q8WXB1

Alternative Names

Methyltransferase Like 21A; Hepatocellular Carcinoma-Associated Antigen 557b; Heat Shock Protein 70kDa Lysine (K) Methyltransferase; Family With Sequence Similarity 119, Member A; Methyltransferase-Like Protein 21A; HSPA Lysine Methyltransferase;

Function

S-adenosyl-L-methionine-dependent methyltransferase that mediates N3-methylcytidine modification of residue 32 of the tRNA anticodon loop of tRNA(Thr)(UGU) and tRNA(Arg)(CCU) (PubMed:28655767, PubMed:34268557).

N3-methylcytidine methylation by METTL2A requires the N6-threonylcarbamoylation of tRNA (t6A37) by the EKC/KEOPS complex as prerequisite (PubMed:34268557).

Biological Process

tRNA methylation Source: UniProtKB

Cellular Location

Cytoplasm

Li, J., Feng, S., Ma, X., Yuan, S., & Wang, X. (2022). METTL21A, a non-histone methyltransferase, is dispensable for spermatogenesis and male fertility in mice. International Journal of Molecular Sciences, 23(4), 1942.

Yang, X., Zoabi, M., Hausmann, S., Flores, N. M., Lu, X., Wu, J., ... & Mazur, P. K. (2022). Abstract A080: METTL21A inhibits pancreatic ductal adenocarcinoma tumorigenesis through methylation of HSPA1/8. Cancer Research, 82(22_Supplement), A080-A080.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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