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Mouse Anti-MIB2 (AA 381-480) Recombinant Antibody (CBFYM-2202) (CBMAB-M2385-FY)

This product is mouse antibody that recognizes MIB2. The antibody CBFYM-2202 can be used for immunoassay techniques such as: ELISA, WB.
See all MIB2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYM-2202
Antibody Isotype
IgG2a, k
Application
ELISA, WB

Basic Information

Immunogen
Recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.Immunogen sequence: IGDLDTVKRL QAGHGEWTDD MAPALGRVGK VVKVFGDGNL RVAVAGQRWT FSPSCLVAYR PEEDANLDVA ERARENKSSL SVALDKLRAQ KSDPEHPGRL
Specificity
Human
Antibody Isotype
IgG2a, k
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 381-480

Target

Full Name
mindbomb homolog 2 (Drosophila)
Introduction
The protein encoded by this gene is an E3 ubiquitin protein ligase that mediates ubiquitination of proteins in the Notch signaling pathway. The encoded protein may be a suppressor of melanoma invasion.
Entrez Gene ID
142678
UniProt ID
Q96AX9
Alternative Names
Mindbomb E3 Ubiquitin Protein Ligase 2; Zinc Finger ZZ Type With Ankyrin Repeat Domain Protein 1; Zinc Finger, ZZ Type With Ankyrin Repeat Domain 1; Putative NF-Kappa-B-Activating Protein 002N; RING-Type E3 Ubiquitin Transferase MIB2; Novel Zinc Finger Protein; Mind Bomb Homolog 2; Skeletrophin; Novelzin; ZZANK1
Function
E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors.
Biological Process
Notch signaling pathway Source: UniProtKB-KW
Positive regulation of I-kappaB kinase/NF-kappaB signaling Source: UniProtKB
Protein ubiquitination Source: GO_Central
Cellular Location
Cytoplasm
Endosome
Note: Colocalizes with endosomal compartments.
PTM
Ubiquitinated. Possibly via autoubiquitination (By similarity).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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