MIB2

The protein encoded by this gene is an E3 ubiquitin protein ligase that mediates ubiquitination of proteins in the Notch signaling pathway. The encoded protein may be a suppressor of melanoma invasion.

Full Name

mindbomb homolog 2 (Drosophila)

Function

E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors.

Biological Process

Notch signaling pathway Source: UniProtKB-KW
Positive regulation of I-kappaB kinase/NF-kappaB signaling Source: UniProtKB
Protein ubiquitination Source: GO_Central

Cellular Location

Cytoplasm
Endosome
Note: Colocalizes with endosomal compartments.

PTM

Ubiquitinated. Possibly via autoubiquitination (By similarity).

Anti-MIB2 antibodies

Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

Mouse Anti-MIB2 Recombinant Antibody (3A7) (CBMAB-A5480-LY)

Datasheet

SDS

Target: MIB2

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: 3A7

Application*: SE, E

Mouse Anti-MIB2 Recombinant Antibody (CBXS-5637) (CBMAB-S0514-CQ)

Datasheet

SDS

Target: MIB2

Host: Mouse

Antibody Isotype: IgG2

Specificity: Human

Clone: CBXS-5637

Application*: WB, E, P

Mouse Anti-MIB2 (AA 418-520) Recombinant Antibody (CBFYM-2203) (CBMAB-M2386-FY)

Datasheet

SDS

Target: MIB2

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: CBFYM-2203

Application*: IC, IF

Mouse Anti-MIB2 (AA 381-480) Recombinant Antibody (CBFYM-2202) (CBMAB-M2385-FY)

Datasheet

SDS

Target: MIB2

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: CBFYM-2202

Application*: E, WB

More Infomation

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)