MIB2

The protein encoded by this gene is an E3 ubiquitin protein ligase that mediates ubiquitination of proteins in the Notch signaling pathway. The encoded protein may be a suppressor of melanoma invasion.
Full Name
mindbomb homolog 2 (Drosophila)
Function
E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors.
Biological Process
Notch signaling pathway Source: UniProtKB-KW
Positive regulation of I-kappaB kinase/NF-kappaB signaling Source: UniProtKB
Protein ubiquitination Source: GO_Central
Cellular Location
Cytoplasm
Endosome
Note: Colocalizes with endosomal compartments.
PTM
Ubiquitinated. Possibly via autoubiquitination (By similarity).
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Anti-MIB2 antibodies

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Mouse Anti-MIB2 Recombinant Antibody (3A7) (CBMAB-A5480-LY)

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Target: MIB2
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 3A7
Application*: SE, E
Datasheet SDS

Human MIB2 ELISA Kit (V2LY-0626-LY4519)

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Target: MIB2
Sensitivity: 0.008 ng/mL
Detection Range: 0.015-3 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Human
Assay Type: Sandwich
Reactivity: Human
Datasheet SDS

Mouse Anti-MIB2 Recombinant Antibody (CBXS-5637) (CBMAB-S0514-CQ)

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Target: MIB2
Host: Mouse
Antibody Isotype: IgG2
Specificity: Human
Clone: CBXS-5637
Application*: WB, E, P
Datasheet SDS

Mouse Anti-MIB2 (AA 418-520) Recombinant Antibody (CBFYM-2203) (CBMAB-M2386-FY)

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Target: MIB2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBFYM-2203
Application*: IC, IF
Datasheet SDS

Mouse Anti-MIB2 (AA 381-480) Recombinant Antibody (CBFYM-2202) (CBMAB-M2385-FY)

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Target: MIB2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBFYM-2202
Application*: E, WB
Datasheet SDS
More Infomation
Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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