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MIB2

The protein encoded by this gene is an E3 ubiquitin protein ligase that mediates ubiquitination of proteins in the Notch signaling pathway. The encoded protein may be a suppressor of melanoma invasion.

Full Name

mindbomb homolog 2 (Drosophila)

Function

E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors.

Biological Process

Notch signaling pathway Source: UniProtKB-KW
Positive regulation of I-kappaB kinase/NF-kappaB signaling Source: UniProtKB
Protein ubiquitination Source: GO_Central

Cellular Location

Cytoplasm
Endosome
Note: Colocalizes with endosomal compartments.

PTM

Ubiquitinated. Possibly via autoubiquitination (By similarity).

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Anti-MIB2 antibodies

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Mouse Anti-MIB2 Recombinant Antibody (3A7) (CBMAB-A5480-LY)

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Target: MIB2

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: 3A7

Application*: SE, E

Mouse Anti-MIB2 Recombinant Antibody (CBXS-5637) (CBMAB-S0514-CQ)

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Target: MIB2

Host: Mouse

Antibody Isotype: IgG2

Specificity: Human

Clone: CBXS-5637

Application*: WB, E, P

Mouse Anti-MIB2 (AA 418-520) Recombinant Antibody (CBFYM-2203) (CBMAB-M2386-FY)

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Target: MIB2

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: CBFYM-2203

Application*: IC, IF

Mouse Anti-MIB2 (AA 381-480) Recombinant Antibody (CBFYM-2202) (CBMAB-M2385-FY)

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Target: MIB2

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: CBFYM-2202

Application*: E, WB

More Infomation

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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