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Mouse Anti-WDR83 Recombinant Antibody (4E12) (CBMAB-A5549-LY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
4E12
Antibody Isotype
IgG2a, κ
Application
WB, ELISA

Basic Information

Immunogen
MORG1 (NP_115708, 171 a.a. ~ 262 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
WD REPEAT DOMAIN 83
Entrez Gene ID
84292
UniProt ID
Q9BRX9
Alternative Names
MGC4238
Function
Molecular scaffold protein for various multimeric protein complexes. Acts as a module in the assembly of a multicomponent scaffold for the ERK pathway, linking ERK responses to specific agonists. At low concentrations it enhances ERK activation, whereas high concentrations lead to the inhibition of ERK activation. Also involved in response to hypoxia by acting as a negative regulator of HIF1A/HIF-1-alpha via its interaction with EGLN3/PHD3. May promote degradation of HIF1A. May act by recruiting signaling complexes to a specific upstream activator (By similarity).
May also be involved in pre-mRNA splicing.
Biological Process
Biological Process inflammatory response to wounding Source:Ensembl
Biological Process mRNA splicing, via spliceosome Source:UniProtKB1 Publication
Biological Process regulation of I-kappaB kinase/NF-kappaB signaling Source:Ensembl
Biological Process response to hypoxia Source:Ensembl
Biological Process response to lipopolysaccharide Source:Ensembl
Biological Process RNA splicing, via transesterification reactions Source:UniProtKB1 Publication
Cellular Location
Cytoplasm
Nucleus
Predominantly cytoplasmic. Partially nuclear.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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