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Mouse Anti-MYCN Recombinant Antibody (NMYC-1) (CBMAB-N0090-WJ)

This product is a Mouse antibody that recognizes MYCN. The antibody NMYC-1 can be used for immunoassay techniques such as: WB, ChIP, FC, IF, IP, CyTOF.
See all MYCN antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse
Clone
NMYC-1
Antibody Isotype
IgG2a, κ
Application
WB, ChIP, FC, IF, IP, CyTOF

Basic Information

Specificity
Human, Mouse
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Concentration
1.0 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
MYCN
Introduction
This gene is a member of the MYC family and encodes a protein with a basic helix-loop-helix (bHLH) domain. This protein is located in the nucleus and must dimerize with another bHLH protein in order to bind DNA. Amplification of this gene is associated with a variety of tumors, most notably neuroblastomas. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2014]
Entrez Gene ID
Human4613
Mouse18109
UniProt ID
HumanP04198
MouseP03966
Alternative Names
MYCN Proto-Oncogene, BHLH Transcription Factor; V-Myc Avian Myelocytomatosis Viral Oncogene Neuroblastoma Derived Homolog; Class E Basic Helix-Loop-Helix Protein 37; BHLHe37; NMYC; Neuroblastoma-Derived V-Myc Avian Myelocytomatosis Viral Related Oncogene; N-Myc Proto-Oncogene Protein;
Function
Positively regulates the transcription of MYCNOS in neuroblastoma cells.
Biological Process
Negative regulation of gene expression Source: BHF-UCL
Positive regulation of gene expression Source: BHF-UCL
Positive regulation of production of miRNAs involved in gene silencing by miRNA Source: BHF-UCL
Positive regulation of transcription, DNA-templated Source: UniProtKB
Positive regulation of transcription by RNA polymerase II Source: NTNU_SB
Regulation of transcription by RNA polymerase II Source: GO_Central
Cellular Location
Nucleus
Involvement in disease
Amplification of the N-MYC gene is associated with a variety of human tumors, most frequently neuroblastoma, where the level of amplification appears to increase as the tumor progresses.
Feingold syndrome 1 (FGLDS1):
A syndrome characterized by variable combinations of esophageal and duodenal atresias, microcephaly, learning disability, mental retardation, and limb malformations. Hand and foot abnormalities may include hypoplastic thumbs, clinodactyly of second and fifth fingers, syndactyly (characteristically between second and third and fourth and fifth toes), and shortened or absent middle phalanges. Cardiac and renal malformations, vertebral anomalies, and deafness have also been described.
PTM
Phosphorylated by GSK3-beta which may promote its degradation (PubMed:24391509). Phosphorylated by AURKA (PubMed:27837025).

Bhardwaj, N., Das, G., & Srinivasan, R. (2023). Neuroblastoma-derived v-myc avian myelocytomatosis viral related oncogene or MYCN gene. Journal of Clinical Pathology.

Pouliou, M., Koutsi, M. A., Champezou, L., Giannopoulou, A. I., Vatsellas, G., Piperi, C., & Agelopoulos, M. (2023). MYCN Amplifications and Metabolic Rewiring in Neuroblastoma. Cancers, 15(19), 4803.

Qin, X., & Chen, B. (2023). Comprehensive analysis and validation reveal potential MYCN regulatory biomarkers associated with neuroblastoma prognosis. Journal of Biomolecular Structure and Dynamics, 41(18), 8902-8917.

Liu, R., Shi, P., Wang, Z., Yuan, C., & Cui, H. (2021). Molecular mechanisms of MYCN dysregulation in cancers. Frontiers in Oncology, 10, 625332.

Braoudaki, M., Hatziagapiou, K., Zaravinos, A., & Lambrou, G. I. (2021). MYCN in neuroblastoma:“old wine into new wineskins”. Diseases, 9(4), 78.

Fu, Y., Yuan, S. S., Zhang, L. J., Ji, Z. L., & Quan, X. J. (2020). Atonal bHLH transcription factor 1 is an important factor for maintaining the balance of cell proliferation and differentiation in tumorigenesis. Oncology letters, 20(3), 2595-2605.

Huang, X., Zhao, J., Zhu, J., Chen, S., Fu, W., Tian, X., ... & Zhou, H. (2019). MYCN gene polymorphisms and Wilms tumor susceptibility in Chinese children. Journal of Clinical Laboratory Analysis, 33(9), e22988.

Aygun, N., & Altungoz, O. (2019). MYCN is amplified during S phase, and c‑myb is involved in controlling MYCN expression and amplification in MYCN‑amplified neuroblastoma cell lines. Molecular medicine reports, 19(1), 345-361.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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