Human MYCN ELISA Kit (V2LY-0626-LY4961)

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Tested Data
Datasheet
SDS
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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Sensitivity
0.0041 ng/mL
Detection Range
0.01-2 ng/mL
Sample Type
Serum, Plasma, cell culture supernates
Specificity
Human
Assay Type
Sandwich
Reactivity
Human
Assay Time
1.5 h
Molecule Mass
49.6 kDa
Components
  • Pre-coated ELISA plate: 12 wells * 8 detachable strips
  • Standard solution: 0.5ml x1
  • Standard diluent: 3ml x1
  • Streptavidin-HRP: 6ml x1
  • Stop solution: 6ml x1
  • Substrate solution A: 6ml x1
  • Substrate solution B: 6ml x1
  • Wash buffer concentrate (25x): 20ml x1
  • Biotinylated antibody: 1ml x1

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 2-8°C
More Infomation

Target

Full Name
MYCN
Function
Positively regulates the transcription of MYCNOS in neuroblastoma cells.
Biological Process
Negative regulation of gene expression Source: BHF-UCL
Positive regulation of gene expression Source: BHF-UCL
Positive regulation of production of miRNAs involved in gene silencing by miRNA Source: BHF-UCL
Positive regulation of transcription, DNA-templated Source: UniProtKB
Positive regulation of transcription by RNA polymerase II Source: NTNU_SB
Regulation of transcription by RNA polymerase II Source: GO_Central
Cellular Location
Nucleus
Involvement in disease
Amplification of the N-MYC gene is associated with a variety of human tumors, most frequently neuroblastoma, where the level of amplification appears to increase as the tumor progresses.
Feingold syndrome 1 (FGLDS1):
A syndrome characterized by variable combinations of esophageal and duodenal atresias, microcephaly, learning disability, mental retardation, and limb malformations. Hand and foot abnormalities may include hypoplastic thumbs, clinodactyly of second and fifth fingers, syndactyly (characteristically between second and third and fourth and fifth toes), and shortened or absent middle phalanges. Cardiac and renal malformations, vertebral anomalies, and deafness have also been described.
PTM
Phosphorylated by GSK3-beta which may promote its degradation (PubMed:24391509). Phosphorylated by AURKA (PubMed:27837025).

Bhardwaj, N., Das, G., & Srinivasan, R. (2023). Neuroblastoma-derived v-myc avian myelocytomatosis viral related oncogene or MYCN gene. Journal of Clinical Pathology.

Pouliou, M., Koutsi, M. A., Champezou, L., Giannopoulou, A. I., Vatsellas, G., Piperi, C., & Agelopoulos, M. (2023). MYCN Amplifications and Metabolic Rewiring in Neuroblastoma. Cancers, 15(19), 4803.

Qin, X., & Chen, B. (2023). Comprehensive analysis and validation reveal potential MYCN regulatory biomarkers associated with neuroblastoma prognosis. Journal of Biomolecular Structure and Dynamics, 41(18), 8902-8917.

Liu, R., Shi, P., Wang, Z., Yuan, C., & Cui, H. (2021). Molecular mechanisms of MYCN dysregulation in cancers. Frontiers in Oncology, 10, 625332.

Braoudaki, M., Hatziagapiou, K., Zaravinos, A., & Lambrou, G. I. (2021). MYCN in neuroblastoma:“old wine into new wineskins”. Diseases, 9(4), 78.

Fu, Y., Yuan, S. S., Zhang, L. J., Ji, Z. L., & Quan, X. J. (2020). Atonal bHLH transcription factor 1 is an important factor for maintaining the balance of cell proliferation and differentiation in tumorigenesis. Oncology letters, 20(3), 2595-2605.

Huang, X., Zhao, J., Zhu, J., Chen, S., Fu, W., Tian, X., ... & Zhou, H. (2019). MYCN gene polymorphisms and Wilms tumor susceptibility in Chinese children. Journal of Clinical Laboratory Analysis, 33(9), e22988.

Aygun, N., & Altungoz, O. (2019). MYCN is amplified during S phase, and c‑myb is involved in controlling MYCN expression and amplification in MYCN‑amplified neuroblastoma cell lines. Molecular medicine reports, 19(1), 345-361.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Human Recombinant MYCN protein, GST Tag (CAT#: V2LY-0526-LY5670)

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For research use only. Not intended for any clinical use.

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