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MYCN

This gene is a member of the MYC family and encodes a protein with a basic helix-loop-helix (bHLH) domain. This protein is located in the nucleus and must dimerize with another bHLH protein in order to bind DNA. Amplification of this gene is associated with a variety of tumors, most notably neuroblastomas. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2014]
Full Name
MYCN
Function
Positively regulates the transcription of MYCNOS in neuroblastoma cells.
Biological Process
Negative regulation of gene expression Source: BHF-UCL
Positive regulation of gene expression Source: BHF-UCL
Positive regulation of production of miRNAs involved in gene silencing by miRNA Source: BHF-UCL
Positive regulation of transcription, DNA-templated Source: UniProtKB
Positive regulation of transcription by RNA polymerase II Source: NTNU_SB
Regulation of transcription by RNA polymerase II Source: GO_Central
Cellular Location
Nucleus
Involvement in disease
Amplification of the N-MYC gene is associated with a variety of human tumors, most frequently neuroblastoma, where the level of amplification appears to increase as the tumor progresses.
Feingold syndrome 1 (FGLDS1):
A syndrome characterized by variable combinations of esophageal and duodenal atresias, microcephaly, learning disability, mental retardation, and limb malformations. Hand and foot abnormalities may include hypoplastic thumbs, clinodactyly of second and fifth fingers, syndactyly (characteristically between second and third and fourth and fifth toes), and shortened or absent middle phalanges. Cardiac and renal malformations, vertebral anomalies, and deafness have also been described.
PTM
Phosphorylated by GSK3-beta which may promote its degradation (PubMed:24391509). Phosphorylated by AURKA (PubMed:27837025).
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Anti-MYCN antibodies

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Mouse Anti-MYCN Recombinant Antibody (CBFYM-0763) (CBMAB-M0906-FY)

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Target: MYCN
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBFYM-0763
Application*: IH, WB
Datasheet SDS

Mouse Anti-MYCN Recombinant Antibody (C-4) (CBMAB-N0981-WJ)

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Target: MYCN
Host: Mouse
Specificity: Human, Mouse, Rat
Clone: C-4
Application*: WB, IP, IF, E
Datasheet SDS

Mouse Anti-MYCN Antibody (1A9) (CBMAB-0689-YC)

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Target: MYCN
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1A9
Application*: WB, M
Datasheet SDS

Mouse Anti-MYCN Recombinant Antibody (CBT2152) (V2LY-0625-LY1464)

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Target: MYCN
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT2152
Application*: IH, F
Datasheet SDS

Rabbit Anti-MYCN Recombinant Antibody (D4B2Y) (CBMAB-CP1624-LY)

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Target: MYCN
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: D4B2Y
Application*: WB, IP, P, CI, CI-seq
Datasheet SDS

Rabbit Anti-MYCN Recombinant Antibody (D1V2A) (CBMAB-CP1623-LY)

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Target: MYCN
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse
Clone: D1V2A
Application*: WB, IP, IF (IC), F, CI, CI-seq
Datasheet SDS

Mouse Anti-MYCN Recombinant Antibody (4H4) (CBMAB-A5717-LY)

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Target: MYCN
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 4H4
Application*: WB, E
Datasheet SDS

Mouse Anti-MYCN Recombinant Antibody (3H4) (CBMAB-A5716-LY)

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Target: MYCN
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 3H4
Application*: WB, E
Datasheet SDS

Mouse Anti-MYCN (AA 1-101) Recombinant Antibody (CBFYM-2897) (CBMAB-M3091-FY)

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Target: MYCN
Host: Mouse
Antibody Isotype: IgG, κ
Specificity: Human
Clone: CBFYM-2897
Application*: WB
Datasheet SDS

Mouse Anti-MYCN (AA 229-464) Recombinant Antibody (CBFYM-2896) (CBMAB-M3090-FY)

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Target: MYCN
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYM-2896
Application*: WB
Datasheet SDS

Rabbit Anti-MYCN Recombinant Antibody (CBWJN-1144) (CBMAB-N0984-WJ)

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Target: MYCN
Host: Rabbit
Specificity: Human, Mouse, Rat
Clone: CBWJN-1144
Application*: WB, IP, P, CI
Datasheet SDS

Mouse Anti-MYCN Recombinant Antibody (CBWJN-1143) (CBMAB-N0983-WJ)

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Target: MYCN
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBWJN-1143
Application*: WB, SE, E, WB, P
Datasheet SDS

Mouse Anti-MYCN Recombinant Antibody (CBWJN-0731) (CBMAB-N0982-WJ)

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Target: MYCN
Host: Mouse
Antibody Isotype: IgG1
Specificity: Mouse, Human
Clone: CBWJN-0731
Application*: WB, IP, C, F, CI, IC
Datasheet SDS

Mouse Anti-MYCN Recombinant Antibody (6A4I) (CBMAB-N0980-WJ)

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Target: MYCN
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Mouse, Rat, Human
Clone: 6A4I
Application*: WB, F
Datasheet SDS

Mouse Anti-MYCN Recombinant Antibody (13A10) (CBMAB-N0979-WJ)

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Target: MYCN
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: 13A10
Application*: WB
Datasheet SDS

Mouse Anti-MYCN Recombinant Antibody (NMYC-1) (CBMAB-N0090-WJ)

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Target: MYCN
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Mouse
Clone: NMYC-1
Application*: WB, CI, F, IF, IP, MC
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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