Mouse Anti-MYL1 Recombinant Antibody (CBFYM-2946) (CBMAB-M3141-FY)

Name: Mouse Anti-MYL1 Recombinant Antibody (CBFYM-2946)
SKU: CBMAB-M3141-FY
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBFYM-2946

Application

WB, ICC, IHC-P, IHC-Fr, ELISA

Immunogen

Myosin Light Chain 1, Alkali, Fast Skeletal

Specificity

Human

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.4, 50% glycerol

Preservative

0.02% Sodium azide

Concentration

0.5 mg/mL

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Myosin Light Chain 1

Introduction

Myosin is a hexameric ATPase cellular motor protein. It is composed of two heavy chains, two nonphosphorylatable alkali light chains, and two phosphorylatable regulatory light chains. This gene encodes a myosin alkali light chain expressed in fast skeletal muscle. Two transcript variants have been identified for this gene.

Entrez Gene ID

4632

UniProt ID

P05976

Alternative Names

Myosin Light Chain 1; Myosin, Light Polypeptide 1, Alkali; Skeletal, Fast; Myosin, Light Chain 1, Alkali; Skeletal, Fast; Myosin Light Chain Alkali 1/2; Myosin Light Chain A1/A2; MLC1F/MLC3F; MLC1/MLC3

Function

Non-regulatory myosin light chain required for proper formation and/or maintenance of myofibers, and thus appropriate muscle function.

Biological Process

Muscle contraction Source: BHF-UCL
Muscle filament sliding Source: BHF-UCL

Cellular Location

Cytoskeleton
muscle myosin complex
myosin II complex
Cytosol
Other locations
contractile fiber
myofibril
sarcomere

Involvement in disease

Myopathy, congenital, with fast-twitch type II fiber atrophy (MYOFTA):
An autosomal recessive congenital myopathy characterized by decreased fetal movements, severe muscle weakness and respiratory failure. Additional features include delayed motor development, areflexia, facial weakness, normal eye movements, head lag, and mild contractures. Skeletal muscle biopsy shows variation in fiber size with atrophy of the fast-twitch type II fibers.

PTM

Isoform MLC3:
Acetylated at position 2.

Li, C., Guan, R., Li, W., Wei, D., Cao, S., Chang, F., ... & Lei, D. (2023). Analysis of myosin genes in HNSCC and identify MYL1 as a specific poor prognostic biomarker, promotes tumor metastasis and correlates with tumor immune infiltration in HNSCC. BMC cancer, 23(1), 840.

Chen, Z., Li, X. Y., Guo, P., & Wang, D. L. (2021). MYBPC2 and MYL1 as significant gene markers for rhabdomyosarcoma. Technology in Cancer Research & Treatment, 20, 1533033820979669.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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