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MYL1

Myosin is a hexameric ATPase cellular motor protein. It is composed of two heavy chains, two nonphosphorylatable alkali light chains, and two phosphorylatable regulatory light chains. This gene encodes a myosin alkali light chain expressed in fast skeletal muscle. Two transcript variants have been identified for this gene. [provided by RefSeq, Jul 2008]
Full Name
Myosin Light Chain 1
Function
Non-regulatory myosin light chain required for proper formation and/or maintenance of myofibers, and thus appropriate muscle function.
Biological Process
Muscle contraction Source: BHF-UCL
Muscle filament sliding Source: BHF-UCL
Cellular Location
Cytoskeleton
muscle myosin complex
myosin II complex
Cytosol
Other locations
contractile fiber
myofibril
sarcomere
Involvement in disease
Myopathy, congenital, with fast-twitch type II fiber atrophy (MYOFTA):
An autosomal recessive congenital myopathy characterized by decreased fetal movements, severe muscle weakness and respiratory failure. Additional features include delayed motor development, areflexia, facial weakness, normal eye movements, head lag, and mild contractures. Skeletal muscle biopsy shows variation in fiber size with atrophy of the fast-twitch type II fibers.
PTM
Isoform MLC3:
Acetylated at position 2.
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Anti-MYL1 antibodies

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Mouse Anti-MYL1 Recombinant Antibody (MY-38) (CBMAB-AO762LY)

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Target: MYL1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Rat, Mouse, Rabbit
Clone: MY-38
Application*: ELISA, WB, IHC
Datasheet SDS

Mouse Anti-MYL1 Recombinant Antibody (2D9) (CBMAB-A5724-LY)

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Target: MYL1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 2D9
Application*: WB, E
Datasheet SDS

Mouse Anti-MYL1 Recombinant Antibody (CBFYM-2948) (CBMAB-M3143-FY)

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Target: MYL1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Rat
Clone: CBFYM-2948
Application*: WB, IP, IH
Datasheet SDS

Mouse Anti-MYL1 Recombinant Antibody (CBFYM-2946) (CBMAB-M3141-FY)

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Target: MYL1
Host: Mouse
Specificity: Human
Clone: CBFYM-2946
Application*: WB, IC, P, C, E
Datasheet SDS

Mouse Anti-MYL1 Recombinant Antibody (CBFYM-2945) (CBMAB-M3140-FY)

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Target: MYL1
Host: Mouse
Antibody Isotype: IgM
Specificity: Cattle, Chicken, Human, Pig, Rabbit
Clone: CBFYM-2945
Application*: IC, IF, WB
Datasheet SDS

Mouse Anti-MYL1 (AA 1-81) Recombinant Antibody (CBFYM-0497) (CBMAB-M0625-FY)

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Target: MYL1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBFYM-0497
Application*: E, IH, WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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