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Mouse Anti-MYL1 Recombinant Antibody (CBFYM-2948) (CBMAB-M3143-FY)

This product is mouse antibody that recognizes MYL1. The antibody CBFYM-2948 can be used for immunoassay techniques such as: WB, IP, IHC.
See all MYL1 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Rat
Clone
CBFYM-2948
Antibody Isotype
IgG1
Application
WB, IP, IHC

Basic Information

Immunogen
Recognizes human Myosin, fast skeletal
Specificity
Human, Rat
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Myosin Light Chain 1
Introduction
Myosin is a hexameric ATPase cellular motor protein. It is composed of two heavy chains, two nonphosphorylatable alkali light chains, and two phosphorylatable regulatory light chains. This gene encodes a myosin alkali light chain expressed in fast skeletal muscle. Two transcript variants have been identified for this gene.
Entrez Gene ID
Human4632
Rat56781
UniProt ID
HumanP05976
RatP02600
Alternative Names
Myosin Light Chain 1; Myosin, Light Polypeptide 1, Alkali; Skeletal, Fast; Myosin, Light Chain 1, Alkali; Skeletal, Fast; Myosin Light Chain Alkali 1/2; Myosin Light Chain A1/A2; MLC1F/MLC3F; MLC1/MLC3
Function
Non-regulatory myosin light chain required for proper formation and/or maintenance of myofibers, and thus appropriate muscle function.
Biological Process
Muscle contraction Source: BHF-UCL
Muscle filament sliding Source: BHF-UCL
Cellular Location
Cytoskeleton
muscle myosin complex
myosin II complex
Cytosol
Other locations
contractile fiber
myofibril
sarcomere
Involvement in disease
Myopathy, congenital, with fast-twitch type II fiber atrophy (MYOFTA):
An autosomal recessive congenital myopathy characterized by decreased fetal movements, severe muscle weakness and respiratory failure. Additional features include delayed motor development, areflexia, facial weakness, normal eye movements, head lag, and mild contractures. Skeletal muscle biopsy shows variation in fiber size with atrophy of the fast-twitch type II fibers.
PTM
Isoform MLC3:
Acetylated at position 2.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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