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Mouse Anti-MYL9 (Phosphorylated S19) Recombinant Antibody (4i15) (PTM-CBMAB-0408LY)

This antibody is a recombiant antibody against MYL9. The antibody can be used for immunoassay techniques, such as IF, WB.
See all MYL9 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
4i15
Antibody Isotype
IgG1
Application
IF, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
10 mM HEPES, pH 7.5, 150 mM sodium chloride, 0.1 mg/ml BSA, 0.02% sodium azide, 50% glycerol
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
myosin, light chain 9, regulatory
Introduction
Myosin, a structural component of muscle, consists of two heavy chains and four light chains. The protein encoded by this gene is a myosin light chain that may regulate muscle contraction by modulating the ATPase activity of myosin heads. The encoded protein binds calcium and is activated by myosin light chain kinase. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Entrez Gene ID
10398
UniProt ID
P24844
Alternative Names
Myosin Light Chain 9; Myosin Regulatory Light Chain 2, Smooth Muscle Isoform; Myosin, Light Polypeptide 9, Regulatory; Myosin Regulatory Light Chain MRLC1; Myosin, Light Chain 9, Regulatory; Myosin Regulatory Light Chain 1; Myosin Regulatory Light Chain 9; 20 KDa Myosin Light Chain;
Function
Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Implicated in cytokinesis, receptor capping, and cell locomotion (PubMed:11942626, PubMed:2526655).

In myoblasts, may regulate PIEZO1-dependent cortical actomyosin assembly involved in myotube formation (By similarity).
Biological Process
Myofibril assembly Source: GO_Central
Platelet aggregation Source: UniProtKB
Regulation of muscle contraction Source: ProtInc
Cellular Location
Cytoskeleton
Other locations
cell cortex
Note: Colocalizes with F-actin, MYH9 and PIEZO1 at the actomyosin cortex in myoblasts.
Involvement in disease
Megacystis-microcolon-intestinal hypoperistalsis syndrome 4 (MMIHS4):
A form of megacystis-microcolon-intestinal hypoperistalsis syndrome, a congenital visceral myopathy primarily affecting females, and characterized by loss of smooth muscle contraction in the bladder and intestine. Affected individuals present at birth with functional obstruction of intestine, microcolon, dilation of bladder, and secondary hydronephrosis. The majority of cases have a fatal outcome due to malnutrition and sepsis, followed by multiorgan failure. MMIHS4 inheritance is autosomal recessive.
PTM
Phosphorylation increases the actin-activated myosin ATPase activity and thereby regulates the contractile activity. It is required to generate the driving force in the migration of the cells but not necessary for localization of myosin-2 at the leading edge. Phosphorylation is required for myotube formation.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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