Mouse Recombinant MYL9 protein, GST Tag (V2LY-0526-LY8683)

Name: Mouse Recombinant MYL9 protein, GST Tag
SKU: V2LY-0526-LY8683
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

E. coli

Protein Species

Mouse

Tag

GST Tag

Protein Construction

This product is Mouse Recombinant MYL9 protein, GST Tag consist of Amino Acid: Full Length and predicts a molecular mass of 45 kDa.

Molecule Mass

45 kDa

Sequence

Amino Acid: Full Length

Species

Mouse

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

Batch dependent.

Endotoxin

Please contact us for more information.

Format

Liquid

Buffer

PBS

Preservative

None

Storage

Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

More Infomation

Target

Full Name

myosin, light chain 9, regulatory

Function

Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Implicated in cytokinesis, receptor capping, and cell locomotion (PubMed:11942626, PubMed:2526655).

In myoblasts, may regulate PIEZO1-dependent cortical actomyosin assembly involved in myotube formation (By similarity).

Biological Process

Myofibril assembly Source: GO_Central
Platelet aggregation Source: UniProtKB
Regulation of muscle contraction Source: ProtInc

Cellular Location

Cytoskeleton
Other locations
cell cortex
Note: Colocalizes with F-actin, MYH9 and PIEZO1 at the actomyosin cortex in myoblasts.

Involvement in disease

Megacystis-microcolon-intestinal hypoperistalsis syndrome 4 (MMIHS4):
A form of megacystis-microcolon-intestinal hypoperistalsis syndrome, a congenital visceral myopathy primarily affecting females, and characterized by loss of smooth muscle contraction in the bladder and intestine. Affected individuals present at birth with functional obstruction of intestine, microcolon, dilation of bladder, and secondary hydronephrosis. The majority of cases have a fatal outcome due to malnutrition and sepsis, followed by multiorgan failure. MMIHS4 inheritance is autosomal recessive.

PTM

Phosphorylation increases the actin-activated myosin ATPase activity and thereby regulates the contractile activity. It is required to generate the driving force in the migration of the cells but not necessary for localization of myosin-2 at the leading edge. Phosphorylation is required for myotube formation.

Kobayashi, H., Kimura, M. Y., Hasegawa, I., Suganuma, E., Ikehara, Y., Azuma, K., ... & Nakayama, T. (2023). Increased Myosin light chain 9 expression during Kawasaki disease vasculitis. Frontiers in Immunology, 13, 1036672.

Matsushita, K., Kobayashi, S., Akita, H., Konno, M., Asai, A., Noda, T., ... & Ishii, H. (2022). Clinicopathological significance of MYL9 expression in pancreatic ductal adenocarcinoma. Cancer Reports, 5(10), e1582.

Lv, M., Luo, L., & Chen, X. (2022). The landscape of prognostic and immunological role of myosin light chain 9 (MYL9) in human tumors. Immunity, Inflammation and Disease, 10(2), 241-254.

Feng, M., Dong, N., Zhou, X., Ma, L., & Xiang, R. (2022). Myosin light chain 9 promotes the proliferation, invasion, migration and angiogenesis of colorectal cancer cells by binding to Yes-associated protein 1 and regulating Hippo signaling. Bioengineered, 13(1), 96-106.

Yokoyama, M., Kimura, M. Y., Ito, T., Hayashizaki, K., Endo, Y., Wang, Y., ... & Nakayama, T. (2021). Myosin light chain 9/12 regulates the pathogenesis of inflammatory bowel disease. Frontiers in Immunology, 11, 594297.

Kruthika, B. S., Sugur, H., Nandaki, K., Arimappamagan, A., Paturu, K., & Santosh, V. (2019). Expression pattern and prognostic significance of myosin light chain 9 (MYL9): a novel biomarker in glioblastoma. Journal of Clinical Pathology.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Mouse Anti-MYL9 (Phosphorylated S20) Recombinant Antibody (CAT#: PTM-CBMAB-0978LY)

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Human Anti-MYL9 Recombinant Antibody (
6G11) (CAT#: V2LY-0725-LY833)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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