Sign in or Register   Sign in or Register
  |  

Mouse Anti-MYLIP (AA 127-385) Recombinant Antibody (CBFYM-2969) (CBMAB-M3164-FY)

This product is mouse antibody that recognizes MYLIP. The antibody CBFYM-2969 can be used for immunoassay techniques such as: WB.
See all MYLIP antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYM-2969
Antibody Isotype
IgG1
Application
WB

Basic Information

Immunogen
Human recombinant protein fragment corresponding to amino acids 127-385 of human MYLIP (NP_037394) produced in E.coli
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 127-385

Target

Full Name
myosin regulatory light chain interacting protein
Introduction
The ERM protein family members ezrin, radixin, and moesin are cytoskeletal effector proteins linking actin to membrane-bound proteins at the cell surface. Myosin regulatory light chain interacting protein is a novel ERM-like protein that interacts with myosin regulatory light chain and inhibits neurite outgrowth.
Entrez Gene ID
29116
UniProt ID
Q8WY64
Alternative Names
Myosin Regulatory Light Chain Interacting Protein; E3 Ubiquitin Ligase-Inducible Degrader Of The Low Density Lipoprotein Receptor; RING-Type E3 Ubiquitin Transferase MYLIP; Inducible Degrader Of The LDL-Receptor; IDOL; MIR
Function
E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of myosin regulatory light chain (MRLC), LDLR, VLDLR and LRP8. Activity depends on E2 enzymes of the UBE2D family. Proteasomal degradation of MRLC leads to inhibit neurite outgrowth in presence of NGF by counteracting the stabilization of MRLC by saposin-like protein (CNPY2/MSAP) and reducing CNPY2-stimulated neurite outgrowth. Acts as a sterol-dependent inhibitor of cellular cholesterol uptake by mediating ubiquitination and subsequent degradation of LDLR.
Biological Process
Cholesterol homeostasis Source: Ensembl
Negative regulation of low-density lipoprotein particle clearance Source: Ensembl
Negative regulation of neuron projection development Source: UniProtKB
Nervous system development Source: UniProtKB
Positive regulation of protein catabolic process Source: Ensembl
Protein destabilization Source: Ensembl
Protein ubiquitination Source: UniProtKB
Regulation of low-density lipoprotein particle receptor catabolic process Source: Ensembl
Ubiquitin-dependent protein catabolic process Source: GO_Central
Cellular Location
Cytoplasm
Plasma membrane
Cell membrane
PTM
Autoubiquitinated.
Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-MYLIP (AA 127-385) Recombinant Antibody (CBFYM-2969)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare