MYLIP

The ERM protein family members ezrin, radixin, and moesin are cytoskeletal effector proteins linking actin to membrane-bound proteins at the cell surface. Myosin regulatory light chain interacting protein (MYLIP) is a novel ERM-like protein that interacts with myosin regulatory light chain and inhibits neurite outgrowth. [provided by RefSeq]

Full Name

myosin regulatory light chain interacting protein

Function

E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of myosin regulatory light chain (MRLC), LDLR, VLDLR and LRP8. Activity depends on E2 enzymes of the UBE2D family. Proteasomal degradation of MRLC leads to inhibit neurite outgrowth in presence of NGF by counteracting the stabilization of MRLC by saposin-like protein (CNPY2/MSAP) and reducing CNPY2-stimulated neurite outgrowth. Acts as a sterol-dependent inhibitor of cellular cholesterol uptake by mediating ubiquitination and subsequent degradation of LDLR.

Biological Process

Cholesterol homeostasis Source: Ensembl
Negative regulation of low-density lipoprotein particle clearance Source: Ensembl
Negative regulation of neuron projection development Source: UniProtKB
Nervous system development Source: UniProtKB
Positive regulation of protein catabolic process Source: Ensembl
Protein destabilization Source: Ensembl
Protein ubiquitination Source: UniProtKB
Regulation of low-density lipoprotein particle receptor catabolic process Source: Ensembl
Ubiquitin-dependent protein catabolic process Source: GO_Central

Cellular Location

Cytoplasm
Plasma membrane
Cell membrane

PTM

Autoubiquitinated.