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Mouse Anti-TGS1 Recombinant Antibody (3F1) (CBMAB-A5821-LY)

The product is antibody recognizes NCOA6IP. The antibody 3F1 immunoassay techniques such as: sELISA, ELISA.
See all TGS1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
3F1
Antibody Isotype
IgG1, κ
Application
sELISA, ELISA

Basic Information

Immunogen
NCOA6IP (AAH11999, 1 a.a. ~ 141 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Trimethylguanosine Synthase 1
Entrez Gene ID
96764
UniProt ID
Q96RS0
Alternative Names
DKFZp762A163; FLJ22995; NCOA6IP; PIMT; PIPMT
Function
Catalyzes the 2 serial methylation steps for the conversion of the 7-monomethylguanosine (m7G) caps of snRNAs and snoRNAs to a 2,2,7-trimethylguanosine (m(2,2,7)G) cap structure. The enzyme is specific for guanine, and N7 methylation must precede N2 methylation. Hypermethylation of the m7G cap of U snRNAs leads to their concentration in nuclear foci, their colocalization with coilin and the formation of canonical Cajal bodies (CBs). Plays a role in transcriptional regulation.
Biological Process
Biological Process 7-methylguanosine cap hypermethylationSource:BHF-UCL1 Publication
Biological Process 7-methylguanosine RNA cappingSource:InterPro
Biological Process ribonucleoprotein complex biogenesisSource:BHF-UCL1 Publication
Biological Process spliceosomal snRNP assemblySource:Reactome
Cellular Location
Cytoplasm
Nucleus, Cajal body
Nucleus, nucleolus
A 90 kDa isoform is found in the nucleus while a 55 kDa isoform is found in the cytoplasm and colocalizes with the tubulin network.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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