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Mouse Anti-NCOR1 Recombinant Antibody (CBT4264) (V2LY-0625-LY2293)


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Tested Data
Mouse Anti-NCOR1 Recombinant Antibody (CBT4264) (V2LY-0625-LY2293) in WB
Mouse Anti-NCOR1 Recombinant Antibody (CBT4264) (V2LY-0625-LY2293) in WB
Mouse Anti-NCOR1 Recombinant Antibody (CBT4264) (V2LY-0625-LY2293) in IHC
Mouse Anti-NCOR1 Recombinant Antibody (CBT4264) (V2LY-0625-LY2293) in IHC

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBT4264
Antibody Isotype
IgG1
Application
IHC

Basic Information

Immunogen
Purified recombinant fragment of NCOR1 (aa1-192) expressed in E. Coli.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
WB1:500-1:2,000
IHC-P1:200-1:1,000
ELISA1:10,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Supernatant
Preservative
Sodium azide
Concentration
Batch dependent
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Entrez Gene ID
9611
UniProt ID
O75376
Function
Mediates transcriptional repression by certain nuclear receptors (PubMed:20812024).

Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors. Participates in the transcriptional repressor activity produced by BCL6. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024).

Mediates the NR1D1-dependent repression and circadian regulation of TSHB expression (By similarity).

The NCOR1-HDAC3 complex regulates the circadian expression of the core clock gene ARTNL/BMAL1 and the genes involved in lipid metabolism in the liver (By similarity).
Biological Process
Chromatin organization Source: UniProtKB-KW
Locomotor rhythm Source: UniProtKB
Negative regulation of androgen receptor signaling pathway Source: UniProtKB
Negative regulation of fatty acid metabolic process Source: BHF-UCL
Negative regulation of glycolytic process Source: BHF-UCL
Negative regulation of JNK cascade Source: UniProtKB
Negative regulation of production of miRNAs involved in gene silencing by miRNA Source: BHF-UCL
Negative regulation of transcription, DNA-templated Source: UniProtKB
Negative regulation of transcription by RNA polymerase II Source: UniProtKB
Regulation of transcription by RNA polymerase II Source: GO_Central
Spindle assembly Source: UniProtKB
Cellular Location
Nucleus
PTM
Ubiquitinated; mediated by SIAH2 and leading to its subsequent proteasomal degradation.
More Infomation

Ma, X. X., Meng, X. Q., Wang, Y. L., Liu, Y., Shi, X. R., Shao, S., ... & Lu, H. X. (2023). Ncor1 Deficiency Promotes Osteoclastogenesis and Exacerbates Periodontitis. Journal of Dental Research, 102(1), 72-81.

Paluvai, H., Shanmukha, K. D., Tyedmers, J., & Backs, J. (2023). Insights into the function of HDAC3 and NCoR1/NCoR2 co-repressor complex in metabolic diseases. Frontiers in Molecular Biosciences, 10.

Sen, K., Pati, R., Jha, A., Mishra, G. P., Prusty, S., Chaudhary, S., ... & Raghav, S. K. (2023). NCoR1 controls immune tolerance in conventional dendritic cells by fine-tuning glycolysis and fatty acid oxidation. Redox Biology, 59, 102575.

Ritter, M. J., Amano, I., Imai, N., De Oliveira, L. S., Vella, K. R., & Hollenberg, A. N. (2021). Nuclear Receptor CoRepressors, NCOR1 and SMRT, are required for maintaining systemic metabolic homeostasis. Molecular Metabolism, 53, 101315.

Lin, A., Qiu, Z., Zhang, J., & Luo, P. (2021). Effect of NCOR1 mutations on immune microenvironment and efficacy of immune checkpoint inhibitors in patient with bladder cancer. Frontiers in immunology, 12, 630773.

Oppi, S., Nusser-Stein, S., Blyszczuk, P., Wang, X., Jomard, A., Marzolla, V., ... & Stein, S. (2020). Macrophage NCOR1 protects from atherosclerosis by repressing a pro-atherogenic PPARγ signature. European heart journal, 41(9), 995-1005.

Geiger, M. A., Guillaumon, A. T., Paneni, F., Matter, C. M., & Stein, S. (2020). Role of the nuclear receptor corepressor 1 (NCOR1) in atherosclerosis and associated immunometabolic diseases. Frontiers in Immunology, 11, 569358.

Wan, X., Liu, L., Zhou, P., Hui, X., He, Q., Yu, F., ... & Zhang, Y. (2019). The nuclear receptor corepressor NCoR1 regulates hematopoiesis and leukemogenesis in vivo. Blood advances, 3(4), 644-657.

Saito, T., Kuma, A., Sugiura, Y., Ichimura, Y., Obata, M., Kitamura, H., ... & Komatsu, M. (2019). Autophagy regulates lipid metabolism through selective turnover of NCoR1. Nature communications, 10(1), 1567.

Zhou, W., He, Y., Rehman, A. U., Kong, Y., Hong, S., Ding, G., ... & Sun, Z. (2019). Loss of function of NCOR1 and NCOR2 impairs memory through a novel GABAergic hypothalamus–CA3 projection. Nature neuroscience, 22(2), 205-217.

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For research use only. Not intended for any clinical use.

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