NCOR1

This gene encodes a protein that mediates ligand-independent transcription repression of thyroid-hormone and retinoic-acid receptors by promoting chromatin condensation and preventing access of the transcription machinery. It is part of a complex which also includes histone deacetylases and transcriptional regulators similar to the yeast protein Sin3p. This gene is located between the Charcot-Marie-Tooth and Smith-Magenis syndrome critical regions on chromosome 17. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 17 and 20.[provided by RefSeq, Jun 2010]

Full Name

Nuclear Receptor Corepressor 1

Function

Mediates transcriptional repression by certain nuclear receptors (PubMed:20812024).

Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors. Participates in the transcriptional repressor activity produced by BCL6. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024).

Mediates the NR1D1-dependent repression and circadian regulation of TSHB expression (By similarity).

The NCOR1-HDAC3 complex regulates the circadian expression of the core clock gene ARTNL/BMAL1 and the genes involved in lipid metabolism in the liver (By similarity).

Biological Process

Chromatin organization Source: UniProtKB-KW
Locomotor rhythm Source: UniProtKB
Negative regulation of androgen receptor signaling pathway Source: UniProtKB
Negative regulation of fatty acid metabolic process Source: BHF-UCL
Negative regulation of glycolytic process Source: BHF-UCL
Negative regulation of JNK cascade Source: UniProtKB
Negative regulation of production of miRNAs involved in gene silencing by miRNA Source: BHF-UCL
Negative regulation of transcription, DNA-templated Source: UniProtKB
Negative regulation of transcription by RNA polymerase II Source: UniProtKB
Regulation of transcription by RNA polymerase II Source: GO_Central
Spindle assembly Source: UniProtKB

Cellular Location

Nucleus

PTM

Ubiquitinated; mediated by SIAH2 and leading to its subsequent proteasomal degradation.