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Rabbit Anti-NCOR1 Recombinant Antibody (E4S4N) (CBMAB-CP1638-LY)

The product is antibody recognizes NCOR1. The antibody E4S4N immunoassay techniques such as: WB,IP,IHC-P,IF (ICC),CIP.
See all NCOR1 antibodies

Summary

Host Animal
Rabbit
Specificity
Human
Clone
E4S4N
Antibody Isotype
IgG
Application
WB, IP, IHC-P, IF (ICC), CIP

Basic Information

Immunogen
Monoclonal antibody is produced by immunizing animals with recombinant protein specific to the carboxy terminus of human NCoR1 protein.
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
100 µg/ml BSA, 50% glycerol
Preservative
0.02% sodium azide
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Nuclear Receptor Corepressor 1
Introduction
This gene encodes a protein that mediates ligand-independent transcription repression of thyroid-hormone and retinoic-acid receptors by promoting chromatin condensation and preventing access of the transcription machinery. It is part of a complex which also includes histone deacetylases and transcriptional regulators similar to the yeast protein Sin3p. This gene is located between the Charcot-Marie-Tooth and Smith-Magenis syndrome critical regions on chromosome 17. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 17 and 20.[provided by RefSeq, Jun 2010]
Entrez Gene ID
9611
UniProt ID
O75376
Alternative Names
Nuclear Receptor Corepressor 1; Thyroid Hormone- And Retinoic Acid Receptor-Associated Corepressor 1; Protein Phosphatase 1; Regulatory Subunit 109; N-CoR1; N-CoR; Nuclear Receptor Co-Repressor 1;
Function
Mediates transcriptional repression by certain nuclear receptors (PubMed:20812024).

Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors. Participates in the transcriptional repressor activity produced by BCL6. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024).

Mediates the NR1D1-dependent repression and circadian regulation of TSHB expression (By similarity).

The NCOR1-HDAC3 complex regulates the circadian expression of the core clock gene ARTNL/BMAL1 and the genes involved in lipid metabolism in the liver (By similarity).
Biological Process
Chromatin organization Source: UniProtKB-KW
Locomotor rhythm Source: UniProtKB
Negative regulation of androgen receptor signaling pathway Source: UniProtKB
Negative regulation of fatty acid metabolic process Source: BHF-UCL
Negative regulation of glycolytic process Source: BHF-UCL
Negative regulation of JNK cascade Source: UniProtKB
Negative regulation of production of miRNAs involved in gene silencing by miRNA Source: BHF-UCL
Negative regulation of transcription, DNA-templated Source: UniProtKB
Negative regulation of transcription by RNA polymerase II Source: UniProtKB
Regulation of transcription by RNA polymerase II Source: GO_Central
Spindle assembly Source: UniProtKB
Cellular Location
Nucleus
PTM
Ubiquitinated; mediated by SIAH2 and leading to its subsequent proteasomal degradation.

Ma, X. X., Meng, X. Q., Wang, Y. L., Liu, Y., Shi, X. R., Shao, S., ... & Lu, H. X. (2023). Ncor1 Deficiency Promotes Osteoclastogenesis and Exacerbates Periodontitis. Journal of Dental Research, 102(1), 72-81.

Paluvai, H., Shanmukha, K. D., Tyedmers, J., & Backs, J. (2023). Insights into the function of HDAC3 and NCoR1/NCoR2 co-repressor complex in metabolic diseases. Frontiers in Molecular Biosciences, 10.

Sen, K., Pati, R., Jha, A., Mishra, G. P., Prusty, S., Chaudhary, S., ... & Raghav, S. K. (2023). NCoR1 controls immune tolerance in conventional dendritic cells by fine-tuning glycolysis and fatty acid oxidation. Redox Biology, 59, 102575.

Ritter, M. J., Amano, I., Imai, N., De Oliveira, L. S., Vella, K. R., & Hollenberg, A. N. (2021). Nuclear Receptor CoRepressors, NCOR1 and SMRT, are required for maintaining systemic metabolic homeostasis. Molecular Metabolism, 53, 101315.

Lin, A., Qiu, Z., Zhang, J., & Luo, P. (2021). Effect of NCOR1 mutations on immune microenvironment and efficacy of immune checkpoint inhibitors in patient with bladder cancer. Frontiers in immunology, 12, 630773.

Oppi, S., Nusser-Stein, S., Blyszczuk, P., Wang, X., Jomard, A., Marzolla, V., ... & Stein, S. (2020). Macrophage NCOR1 protects from atherosclerosis by repressing a pro-atherogenic PPARγ signature. European heart journal, 41(9), 995-1005.

Geiger, M. A., Guillaumon, A. T., Paneni, F., Matter, C. M., & Stein, S. (2020). Role of the nuclear receptor corepressor 1 (NCOR1) in atherosclerosis and associated immunometabolic diseases. Frontiers in Immunology, 11, 569358.

Wan, X., Liu, L., Zhou, P., Hui, X., He, Q., Yu, F., ... & Zhang, Y. (2019). The nuclear receptor corepressor NCoR1 regulates hematopoiesis and leukemogenesis in vivo. Blood advances, 3(4), 644-657.

Saito, T., Kuma, A., Sugiura, Y., Ichimura, Y., Obata, M., Kitamura, H., ... & Komatsu, M. (2019). Autophagy regulates lipid metabolism through selective turnover of NCoR1. Nature communications, 10(1), 1567.

Zhou, W., He, Y., Rehman, A. U., Kong, Y., Hong, S., Ding, G., ... & Sun, Z. (2019). Loss of function of NCOR1 and NCOR2 impairs memory through a novel GABAergic hypothalamus–CA3 projection. Nature neuroscience, 22(2), 205-217.

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For research use only. Not intended for any clinical use.

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