Rat Anti-NECTIN3 Recombinant Antibody (103-A1) (CBMAB-N1737-WJ)

Name: Rat Anti-NECTIN3 Recombinant Antibody (103-A1)
SKU: CBMAB-N1737-WJ
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Rat

Clone

103-A1

Application

ELISA, FC, IHC, IP, WB

Specificity

Mouse

Antibody Isotype

IgG2a

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, 0.1% BSA

Preservative

0.02% sodium azide

Concentration

1 mg/mL

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Nectin Cell Adhesion Molecule 3

Introduction

This gene encodes a member of the nectin family of proteins, which function as adhesion molecules at adherens junctions. This family member interacts with other nectin-like proteins and with afadin, a filamentous actin-binding protein involved in the regulation of directional motility, cell proliferation and survival. This gene plays a role in ocular development involving the ciliary body. Mutations in this gene are believed to result in congenital ocular defects. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]

Entrez Gene ID

58998

UniProt ID

Q9JLB9

Alternative Names

Nectin Cell Adhesion Molecule 3; Poliovirus Receptor-Related Protein 3; Poliovirus Receptor-Related 3; CDW113; PVRL3; PRR3; CD113 Antigen;

Function

Plays a role in cell-cell adhesion through heterophilic trans-interactions with nectin-like proteins or nectins, such as trans-interaction with NECTIN2 at Sertoli-spermatid junctions. Trans-interaction with PVR induces activation of CDC42 and RAC small G proteins through common signaling molecules such as SRC and RAP1. Also involved in the formation of cell-cell junctions, including adherens junctions and synapses. Induces endocytosis-mediated down-regulation of PVR from the cell surface, resulting in reduction of cell movement and proliferation. Plays a role in the morphology of the ciliary body.

Biological Process

Establishment of protein localization to plasma membrane Source: ARUK-UCL
Fertilization Source: Ensembl
Heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules Source: GO_Central
Homophilic cell adhesion via plasma membrane adhesion molecules Source: HGNC-UCL
Lens morphogenesis in camera-type eye Source: Ensembl
Protein localization to cell junction Source: Ensembl
Retina morphogenesis in camera-type eye Source: Ensembl
Spermatid development Source: InterPro

Cellular Location

Plasma membrane
Cell membrane
postsynaptic cell membrane

Topology

Extracellular: 58-404
Helical: 405-425
Cytoplasmic: 426-549

Zhao, Y., Hong, X. H., Li, K., Li, Y. Q., Li, Y. Q., He, S. W., ... & Chen, Y. P. (2020). ZNF582 hypermethylation promotes metastasis of nasopharyngeal carcinoma by regulating the transcription of adhesion molecules Nectin‐3 and NRXN3. Cancer Communications, 40(12), 721-737.

Hirabayashi, K., Tajiri, T., Bosch, D. E., Morimachi, M., Miyaoka, M., Inomoto, C., ... & Yeh, M. M. (2020). Loss of nectin‐3 expression as a marker of tumor aggressiveness in pancreatic neuroendocrine tumor. Pathology International, 70(2), 84-91.

Xu, F., Si, X., Wang, J., Yang, A., Qin, T., & Yang, Y. (2019). Nectin-3 is a new biomarker that mediates the upregulation of MMP2 and MMP9 in ovarian cancer cells. Biomedicine & Pharmacotherapy, 110, 139-144.

Liu, R., Wang, H., Wang, H. L., Sun, Y. X., Su, Y. A., Wang, X. D., ... & Si, T. M. (2019). Postnatal nectin‐3 knockdown induces structural abnormalities of hippocampal principal neurons and memory deficits in adult mice. Hippocampus, 29(11), 1063-1074.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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