NECTIN3

This gene encodes a member of the nectin family of proteins, which function as adhesion molecules at adherens junctions. This family member interacts with other nectin-like proteins and with afadin, a filamentous actin-binding protein involved in the regulation of directional motility, cell proliferation and survival. This gene plays a role in ocular development involving the ciliary body. Mutations in this gene are believed to result in congenital ocular defects. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]

Full Name

Nectin Cell Adhesion Molecule 3

Function

Plays a role in cell-cell adhesion through heterophilic trans-interactions with nectin-like proteins or nectins, such as trans-interaction with NECTIN2 at Sertoli-spermatid junctions. Trans-interaction with PVR induces activation of CDC42 and RAC small G proteins through common signaling molecules such as SRC and RAP1. Also involved in the formation of cell-cell junctions, including adherens junctions and synapses. Induces endocytosis-mediated down-regulation of PVR from the cell surface, resulting in reduction of cell movement and proliferation. Plays a role in the morphology of the ciliary body.

Biological Process

Establishment of protein localization to plasma membrane Source: ARUK-UCL
Fertilization Source: Ensembl
Heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules Source: GO_Central
Homophilic cell adhesion via plasma membrane adhesion molecules Source: HGNC-UCL
Lens morphogenesis in camera-type eye Source: Ensembl
Protein localization to cell junction Source: Ensembl
Retina morphogenesis in camera-type eye Source: Ensembl
Spermatid development Source: InterPro

Cellular Location

Plasma membrane
Cell membrane
postsynaptic cell membrane

Topology

Extracellular: 58-404
Helical: 405-425
Cytoplasmic: 426-549

Anti-NECTIN3 antibodies

+ Filters

Recombinant Rat Anti-NECTIN3 Antibody (CBHb039) (CBMAB-Hb819-LY)

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Target: NECTIN3

Host: Rat

Antibody Isotype: IgG2a

Specificity: Mouse

Clone: CBHb039

Application*: FC, IHC-F, FuncS, Immuno assays, IF, IP

Datasheet SDS

Mouse Anti-NECTIN3 Recombinant Antibody (CBT4559) (V2LY-0625-LY1190)

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Target: NECTIN3

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBT4559

Application*: F

Datasheet SDS

Mouse Anti-NECTIN3 Recombinant Antibody (1D1) (CBMAB-A7268-LY)

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Target: NECTIN3

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 1D1

Application*: WB, E

Datasheet SDS

Rat Anti-NECTIN3 (AA 50-400) Recombinant Antibody (CBFYA-0024) (CBMAB-X0039-FY)

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Target: NECTIN3

Host: Rat

Antibody Isotype: IgG2a

Specificity: Mouse

Clone: CBFYA-0024

Application*: F, C, FN, IA, IF, IP

Datasheet SDS

Mouse Anti-NECTIN3 Recombinant Antibody (1D1) (CBMAB-P0552-YC)

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Target: NECTIN3

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 1D1

Application*: E, WB

Datasheet SDS

Mouse Anti-NECTIN3 Recombinant Antibody (CBFYC-3005) (CBMAB-C3082-FY)

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Target: NECTIN3

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBFYC-3005

Application*: E

Datasheet SDS

Mouse Anti-NECTIN3 Recombinant Antibody (CBFYC-3004) (CBMAB-C3081-FY)

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Target: NECTIN3

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBFYC-3004

Application*: P

Datasheet SDS

Rat Anti-NECTIN3 (AA 50-400) Recombinant Antibody (CBFYC-3003) (CBMAB-C3080-FY)

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Target: NECTIN3

Host: Rat

Antibody Isotype: IgG2a

Specificity: Mouse

Clone: CBFYC-3003

Application*: IP, IF, E, FN, C

Datasheet SDS

Mouse Anti-NECTIN3 Recombinant Antibody (N3.12.4) (CBMAB-N1740-WJ)

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Target: NECTIN3

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: N3.12.4

Application*: FM, IC, IPP

Datasheet SDS

Rat Anti-NECTIN3 Recombinant Antibody (CBWJN-0448) (CBMAB-N1739-WJ)

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Target: NECTIN3

Host: Rat

Antibody Isotype: IgG2a

Specificity: Mouse

Clone: CBWJN-0448

Application*: F, IH, IP

Datasheet SDS

Rat Anti-NECTIN3 Recombinant Antibody (CBWJN-0122) (CBMAB-N1738-WJ)

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Target: NECTIN3

Host: Rat

Antibody Isotype: IgG2a

Specificity: Mouse

Clone: CBWJN-0122

Application*: F, IF, IH, IP

Datasheet SDS

Rat Anti-NECTIN3 Recombinant Antibody (103-A1) (CBMAB-N1737-WJ)

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Target: NECTIN3

Host: Rat

Antibody Isotype: IgG2a

Specificity: Mouse

Clone: 103-A1

Application*: E, F, IH, IP, WB

Datasheet SDS

Mouse Anti-NECTIN3 Recombinant Antibody (CBWJN-1288) (CBMAB-N1736-WJ)

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Target: NECTIN3

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBWJN-1288

Application*: WB

Datasheet SDS

More Infomation

Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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