NECTIN3

This gene encodes a member of the nectin family of proteins, which function as adhesion molecules at adherens junctions. This family member interacts with other nectin-like proteins and with afadin, a filamentous actin-binding protein involved in the regulation of directional motility, cell proliferation and survival. This gene plays a role in ocular development involving the ciliary body. Mutations in this gene are believed to result in congenital ocular defects. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]

Nectin Cell Adhesion Molecule 3

Plays a role in cell-cell adhesion through heterophilic trans-interactions with nectin-like proteins or nectins, such as trans-interaction with NECTIN2 at Sertoli-spermatid junctions. Trans-interaction with PVR induces activation of CDC42 and RAC small G proteins through common signaling molecules such as SRC and RAP1. Also involved in the formation of cell-cell junctions, including adherens junctions and synapses. Induces endocytosis-mediated down-regulation of PVR from the cell surface, resulting in reduction of cell movement and proliferation. Plays a role in the morphology of the ciliary body.

Establishment of protein localization to plasma membrane Source: ARUK-UCL
Fertilization Source: Ensembl
Heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules Source: GO_Central
Homophilic cell adhesion via plasma membrane adhesion molecules Source: HGNC-UCL
Lens morphogenesis in camera-type eye Source: Ensembl
Protein localization to cell junction Source: Ensembl
Retina morphogenesis in camera-type eye Source: Ensembl
Spermatid development Source: InterPro

Plasma membrane
Cell membrane
postsynaptic cell membrane

Extracellular: 58-404
Helical: 405-425
Cytoplasmic: 426-549