NECTIN3

This gene encodes a member of the nectin family of proteins, which function as adhesion molecules at adherens junctions. This family member interacts with other nectin-like proteins and with afadin, a filamentous actin-binding protein involved in the regulation of directional motility, cell proliferation and survival. This gene plays a role in ocular development involving the ciliary body. Mutations in this gene are believed to result in congenital ocular defects. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]
Full Name
Nectin Cell Adhesion Molecule 3
Function
Plays a role in cell-cell adhesion through heterophilic trans-interactions with nectin-like proteins or nectins, such as trans-interaction with NECTIN2 at Sertoli-spermatid junctions. Trans-interaction with PVR induces activation of CDC42 and RAC small G proteins through common signaling molecules such as SRC and RAP1. Also involved in the formation of cell-cell junctions, including adherens junctions and synapses. Induces endocytosis-mediated down-regulation of PVR from the cell surface, resulting in reduction of cell movement and proliferation. Plays a role in the morphology of the ciliary body.
Biological Process
Establishment of protein localization to plasma membrane Source: ARUK-UCL
Fertilization Source: Ensembl
Heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules Source: GO_Central
Homophilic cell adhesion via plasma membrane adhesion molecules Source: HGNC-UCL
Lens morphogenesis in camera-type eye Source: Ensembl
Protein localization to cell junction Source: Ensembl
Retina morphogenesis in camera-type eye Source: Ensembl
Spermatid development Source: InterPro
Cellular Location
Plasma membrane
Cell membrane
postsynaptic cell membrane
Topology
Extracellular: 58-404
Helical: 405-425
Cytoplasmic: 426-549
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Anti-NECTIN3 antibodies

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Recombinant Rat Anti-NECTIN3 Antibody (CBHb039) (CBMAB-Hb819-LY)

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Target: NECTIN3
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: CBHb039
Application*: FC, IHC-F, FuncS, Immuno assays, IF, IP
Datasheet SDS

Human Recombinant NECTIN3 protein, His Tag (V2LY-0526-LY5712)

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Target: NECTIN3
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-400
Tag: His Tag
Datasheet SDS

Human Recombinant NECTIN3 protein, ECD, hFc Tag (V2LY-0526-LY5711)

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Target: NECTIN3
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-400
Tag: hFc Tag
Datasheet SDS

Mouse Anti-NECTIN3 Recombinant Antibody (CBT4559) (V2LY-0625-LY1190)

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Target: NECTIN3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT4559
Application*: F
Datasheet SDS

Mouse Anti-NECTIN3 Recombinant Antibody (1D1) (CBMAB-A7268-LY)

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Target: NECTIN3
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 1D1
Application*: WB, E
Datasheet SDS

Rat Anti-NECTIN3 (AA 50-400) Recombinant Antibody (CBFYA-0024) (CBMAB-X0039-FY)

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Target: NECTIN3
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: CBFYA-0024
Application*: F, C, FN, IA, IF, IP
Datasheet SDS

Mouse Anti-NECTIN3 Recombinant Antibody (1D1) (CBMAB-P0552-YC)

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Target: NECTIN3
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 1D1
Application*: E, WB
Datasheet SDS

Mouse Anti-NECTIN3 Recombinant Antibody (CBFYC-3005) (CBMAB-C3082-FY)

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Target: NECTIN3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYC-3005
Application*: E
Datasheet SDS

Mouse Anti-NECTIN3 Recombinant Antibody (CBFYC-3004) (CBMAB-C3081-FY)

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Target: NECTIN3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYC-3004
Application*: P
Datasheet SDS

Rat Anti-NECTIN3 (AA 50-400) Recombinant Antibody (CBFYC-3003) (CBMAB-C3080-FY)

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Target: NECTIN3
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: CBFYC-3003
Application*: IP, IF, E, FN, C
Datasheet SDS

Mouse Anti-NECTIN3 Recombinant Antibody (N3.12.4) (CBMAB-N1740-WJ)

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Target: NECTIN3
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: N3.12.4
Application*: FM, IC, IPP
Datasheet SDS

Rat Anti-NECTIN3 Recombinant Antibody (CBWJN-0448) (CBMAB-N1739-WJ)

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Target: NECTIN3
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: CBWJN-0448
Application*: F, IH, IP
Datasheet SDS

Rat Anti-NECTIN3 Recombinant Antibody (CBWJN-0122) (CBMAB-N1738-WJ)

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Target: NECTIN3
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: CBWJN-0122
Application*: F, IF, IH, IP
Datasheet SDS

Rat Anti-NECTIN3 Recombinant Antibody (103-A1) (CBMAB-N1737-WJ)

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Target: NECTIN3
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: 103-A1
Application*: E, F, IH, IP, WB
Datasheet SDS

Mouse Anti-NECTIN3 Recombinant Antibody (CBWJN-1288) (CBMAB-N1736-WJ)

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Target: NECTIN3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJN-1288
Application*: WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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