Mouse Anti-NELL1 Recombinant Antibody (CBWJN-0506) (CBMAB-N1960-WJ)

Name: Mouse Anti-NELL1 Recombinant Antibody (CBWJN-0506)
SKU: CBMAB-N1960-WJ
Rating: 5 (1 reviews)

See all NELL1 antibodies

Compare Online Inquiry

Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBWJN-0506

Application

ELISA, WB

Specificity

Human

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Lyophilized

Buffer

PBS, pH 7.2

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Neural EGFL Like 1

Introduction

This gene encodes a cytoplasmic protein that contains epidermal growth factor (EGF)-like repeats. The encoded heterotrimeric protein may be involved in cell growth regulation and differentiation. A similar protein in rodents is involved in craniosynostosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]

Entrez Gene ID

4745

UniProt ID

Q92832

Alternative Names

Neural EGFL Like 1; Nel-Related Protein 1; NRP1; Protein Kinase C-Binding Protein NELL1; Neural Epidermal Growth Factor-Like 1; Nel (Chicken)-Like 1; NEL-Like 1 (Chicken); NEL-Like Protein 1; IDH3GL;

Function

Plays a role in the control of cell growth and differentiation. Promotes osteoblast cell differentiation and terminal mineralization.

Biological Process

Cell differentiation Source: UniProtKB-KW
Negative regulation of cellular protein catabolic process Source: UniProtKB
Negative regulation of osteoblast proliferation Source: UniProtKB
Nervous system development Source: ProtInc
Positive regulation of bone mineralization Source: UniProtKB
Positive regulation of osteoblast differentiation Source: UniProtKB
Regulation of gene expression Source: UniProtKB

Cellular Location

Nucleus
Nucleus envelope
Cytoplasm
Secreted
Note: Colocalizes with ATRAID on the nuclear envelope and the perinuclear region.

Sethi, S. (2023). The many faces of NELL1 MN. Clinical Kidney Journal, 16(3), 442-446.

Kurien, A. A., Ks, J. P., Walker, P. D., & Caza, T. N. (2022). Traditional indigenous medicines are an etiologic consideration for NELL1-positive membranous nephropathy. Kidney International, 102(6), 1424-1426.

Cheng, X., Shi, J., Jia, Z., Ha, P., Soo, C., Ting, K., ... & Zhang, X. (2022). NELL-1 in genome-wide association studies across human diseases. The American Journal of Pathology, 192(3), 395-405.

Qin, Q., Gomez-Salazar, M., Tower, R. J., Chang, L., Morris, C. D., McCarthy, E. F., ... & James, A. W. (2022). NELL1 regulates the matrisome to promote osteosarcoma progression. Cancer research, 82(15), 2734-2747.

Duan, C., & Townley, H. E. (2022). Isolation of NELL 1 Aptamers for Rhabdomyosarcoma Targeting. Bioengineering, 9(4), 174.

Spain, R. I., Andeen, N. K., Gibson, P. C., Samuels, M. H., Morris, C. D., Solomon, A. J., ... & Avasare, R. S. (2021). Lipoic acid supplementation associated with neural epidermal growth factor-like 1 (NELL1)–associated membranous nephropathy. Kidney International, 100(6), 1208-1213.

Caza, T. N., Hassen, S. I., Dvanajscak, Z., Kuperman, M., Edmondson, R., Herzog, C., ... & Larsen, C. P. (2021). NELL1 is a target antigen in malignancy-associated membranous nephropathy. Kidney international, 99(4), 967-976.

Sethi, S., Debiec, H., Madden, B., Charlesworth, M. C., Morelle, J., Gross, L., ... & Ronco, P. (2020). Neural epidermal growth factor-like 1 protein (NELL-1) associated membranous nephropathy. Kidney International, 97(1), 163-174.

Huang, X., Cen, X., Zhang, B., Liao, Y., Zhao, Z., Zhu, G., ... & Liu, J. (2019). The roles of circRFWD2 and circINO80 during NELL‐1‐induced osteogenesis. Journal of Cellular and Molecular Medicine, 23(12), 8432-8441.

Li, C., Zhang, X., Zheng, Z., Nguyen, A., Ting, K., & Soo, C. (2019). Nell-1 is a key functional modulator in osteochondrogenesis and beyond. Journal of Dental Research, 98(13), 1458-1468.

Ask a question We look forward to hearing from you.

0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Have you used Mouse Anti-NELL1 Recombinant Antibody (CBWJN-0506)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon

$30 eGift Card
Submit a review

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Antibody Pairs

NELL1 Matched Antibody Pair (792) (CAT#: APMAB-792LY)

Related Products

Mouse Anti-NELL1 Recombinant Antibody (3F1) (CAT#: CBMAB-N1958-WJ)

Mouse Anti-NELL1 Recombinant Antibody (CBWJN-1323) (CAT#: CBMAB-N1954-WJ)

Mouse Anti-NELL1 Recombinant Antibody (CBWJN-1324) (CAT#: CBMAB-N1955-WJ)

Mouse Anti-NELL1 Recombinant Antibody (6A8) (CAT#: CBMAB-N1959-WJ)

NELL1 Matched Antibody Pair (792) (CAT#: APMAB-792LY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Request bulk or custom quote Second antibody and isotype control

Contact us

Tel: (USA)
(UK)
Fax:

Global Locations

Email:

Online Inquiry