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NELL1

This gene encodes a cytoplasmic protein that contains epidermal growth factor (EGF)-like repeats. The encoded heterotrimeric protein may be involved in cell growth regulation and differentiation. A similar protein in rodents is involved in craniosynostosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]

Full Name

Neural EGFL Like 1

Function

Plays a role in the control of cell growth and differentiation. Promotes osteoblast cell differentiation and terminal mineralization.

Biological Process

Cell differentiation Source: UniProtKB-KW
Negative regulation of cellular protein catabolic process Source: UniProtKB
Negative regulation of osteoblast proliferation Source: UniProtKB
Nervous system development Source: ProtInc
Positive regulation of bone mineralization Source: UniProtKB
Positive regulation of osteoblast differentiation Source: UniProtKB
Regulation of gene expression Source: UniProtKB

Cellular Location

Nucleus
Nucleus envelope
Cytoplasm
Secreted
Note: Colocalizes with ATRAID on the nuclear envelope and the perinuclear region.

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Anti-NELL1 antibodies

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Mouse Anti-NELL1 Recombinant Antibody (CBWJN-0506) (CBMAB-N1960-WJ)

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Target: NELL1

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CBWJN-0506

Application*: E, WB

Mouse Anti-NELL1 Recombinant Antibody (6A8) (CBMAB-N1959-WJ)

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Target: NELL1

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 6A8

Application*: E, IF, IP, WB

Mouse Anti-NELL1 Recombinant Antibody (3F1) (CBMAB-N1958-WJ)

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Target: NELL1

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 3F1

Application*: E

Mouse Anti-NELL1 Recombinant Antibody (CBWJN-1324) (CBMAB-N1955-WJ)

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Target: NELL1

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: CBWJN-1324

Application*: WB

Mouse Anti-NELL1 Recombinant Antibody (CBWJN-1323) (CBMAB-N1954-WJ)

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Target: NELL1

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: CBWJN-1323

Application*: IC

NELL1 Matched Antibody Pair (792) (APMAB-792LY)

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Target: NELL1

Specificity: Human

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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