NELL1

This gene encodes a cytoplasmic protein that contains epidermal growth factor (EGF)-like repeats. The encoded heterotrimeric protein may be involved in cell growth regulation and differentiation. A similar protein in rodents is involved in craniosynostosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]

Full Name

Neural EGFL Like 1

Function

Plays a role in the control of cell growth and differentiation. Promotes osteoblast cell differentiation and terminal mineralization.

Biological Process

Cell differentiation Source: UniProtKB-KW
Negative regulation of cellular protein catabolic process Source: UniProtKB
Negative regulation of osteoblast proliferation Source: UniProtKB
Nervous system development Source: ProtInc
Positive regulation of bone mineralization Source: UniProtKB
Positive regulation of osteoblast differentiation Source: UniProtKB
Regulation of gene expression Source: UniProtKB

Cellular Location

Nucleus
Nucleus envelope
Cytoplasm
Secreted
Note: Colocalizes with ATRAID on the nuclear envelope and the perinuclear region.

Anti-NELL1 antibodies

Mouse Anti-NELL1 Recombinant Antibody (CBWJN-0506) (CBMAB-N1960-WJ)

Datasheet

SDS

Target: NELL1

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CBWJN-0506

Application*: E, WB

Mouse Anti-NELL1 Recombinant Antibody (6A8) (CBMAB-N1959-WJ)

Datasheet

SDS

Target: NELL1

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 6A8

Application*: E, IF, IP, WB

Mouse Anti-NELL1 Recombinant Antibody (3F1) (CBMAB-N1958-WJ)

Datasheet

SDS

Target: NELL1

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 3F1

Application*: E

Mouse Anti-NELL1 Recombinant Antibody (CBWJN-1324) (CBMAB-N1955-WJ)

Datasheet

SDS

Target: NELL1

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: CBWJN-1324

Application*: WB

Mouse Anti-NELL1 Recombinant Antibody (CBWJN-1323) (CBMAB-N1954-WJ)

Datasheet

SDS

Target: NELL1

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: CBWJN-1323

Application*: IC

NELL1 Matched Antibody Pair (792) (APMAB-792LY)

Datasheet

SDS

Target: NELL1

Specificity: Human

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)