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Mouse Anti-NELL1 Recombinant Antibody (CBWJN-1323) (CBMAB-N1954-WJ)

This product is a Mouse antibody that recognizes NELL1. The antibody CBWJN-1323 can be used for immunoassay techniques such as: ICC.
See all NELL1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBWJN-1323
Antibody Isotype
IgG2b
Application
ICC

Basic Information

Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Buffer
PBS, Trehalose
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Neural EGFL Like 1
Introduction
This gene encodes a cytoplasmic protein that contains epidermal growth factor (EGF)-like repeats. The encoded heterotrimeric protein may be involved in cell growth regulation and differentiation. A similar protein in rodents is involved in craniosynostosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]
Entrez Gene ID
4745
UniProt ID
Q92832
Alternative Names
Neural EGFL Like 1; Nel-Related Protein 1; NRP1; Protein Kinase C-Binding Protein NELL1; Neural Epidermal Growth Factor-Like 1; Nel (Chicken)-Like 1; NEL-Like 1 (Chicken); NEL-Like Protein 1; IDH3GL;
Function
Plays a role in the control of cell growth and differentiation. Promotes osteoblast cell differentiation and terminal mineralization.
Biological Process
Cell differentiation Source: UniProtKB-KW
Negative regulation of cellular protein catabolic process Source: UniProtKB
Negative regulation of osteoblast proliferation Source: UniProtKB
Nervous system development Source: ProtInc
Positive regulation of bone mineralization Source: UniProtKB
Positive regulation of osteoblast differentiation Source: UniProtKB
Regulation of gene expression Source: UniProtKB
Cellular Location
Nucleus
Nucleus envelope
Cytoplasm
Secreted
Note: Colocalizes with ATRAID on the nuclear envelope and the perinuclear region.

Sethi, S. (2023). The many faces of NELL1 MN. Clinical Kidney Journal, 16(3), 442-446.

Kurien, A. A., Ks, J. P., Walker, P. D., & Caza, T. N. (2022). Traditional indigenous medicines are an etiologic consideration for NELL1-positive membranous nephropathy. Kidney International, 102(6), 1424-1426.

Cheng, X., Shi, J., Jia, Z., Ha, P., Soo, C., Ting, K., ... & Zhang, X. (2022). NELL-1 in genome-wide association studies across human diseases. The American Journal of Pathology, 192(3), 395-405.

Qin, Q., Gomez-Salazar, M., Tower, R. J., Chang, L., Morris, C. D., McCarthy, E. F., ... & James, A. W. (2022). NELL1 regulates the matrisome to promote osteosarcoma progression. Cancer research, 82(15), 2734-2747.

Duan, C., & Townley, H. E. (2022). Isolation of NELL 1 Aptamers for Rhabdomyosarcoma Targeting. Bioengineering, 9(4), 174.

Spain, R. I., Andeen, N. K., Gibson, P. C., Samuels, M. H., Morris, C. D., Solomon, A. J., ... & Avasare, R. S. (2021). Lipoic acid supplementation associated with neural epidermal growth factor-like 1 (NELL1)–associated membranous nephropathy. Kidney International, 100(6), 1208-1213.

Caza, T. N., Hassen, S. I., Dvanajscak, Z., Kuperman, M., Edmondson, R., Herzog, C., ... & Larsen, C. P. (2021). NELL1 is a target antigen in malignancy-associated membranous nephropathy. Kidney international, 99(4), 967-976.

Sethi, S., Debiec, H., Madden, B., Charlesworth, M. C., Morelle, J., Gross, L., ... & Ronco, P. (2020). Neural epidermal growth factor-like 1 protein (NELL-1) associated membranous nephropathy. Kidney International, 97(1), 163-174.

Huang, X., Cen, X., Zhang, B., Liao, Y., Zhao, Z., Zhu, G., ... & Liu, J. (2019). The roles of circRFWD2 and circINO80 during NELL‐1‐induced osteogenesis. Journal of Cellular and Molecular Medicine, 23(12), 8432-8441.

Li, C., Zhang, X., Zheng, Z., Nguyen, A., Ting, K., & Soo, C. (2019). Nell-1 is a key functional modulator in osteochondrogenesis and beyond. Journal of Dental Research, 98(13), 1458-1468.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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