Mouse Anti-NETO1 Recombinant Antibody (A1328) (CBMAB-AP5058LY)

The product is antibody recognizes NETO1. The antibody A1328 immunoassay techniques such as: ICC, IHC, WB.
See all NETO1 antibodies

Datasheet

Summary

Host Animal

Mouse

Specificity

Human, Mouse

Clone

A1328

Antibody Isotype

IgM

Application

ICC, IHC, WB

Basic Information

Immunogen

Recombinant Neuropilin and tolloid like 1 protein.

Specificity

Human, Mouse

Antibody Isotype

IgM

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Purity

Affinity purity

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name

Neuropilin And Tolloid Like 1

Introduction

This gene encodes a transmembrane protein containing two extracellular CUB domains followed by a low-density lipoprotein class A (LDLa) domain. This protein is thought to play a critical role in spatial learning and memory by regulating the function of synaptic N-methyl-D-aspartic acid receptor complexes in the hippocampus. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2017]

Entrez Gene ID

Human	81832
Mouse	246317

UniProt ID

Human	Q8TDF5
Mouse	Q8R4I7

Alternative Names

Neuropilin And Tolloid Like 1; Brain-Specific Transmembrane Protein Containing 2 CUB And 1 LDL-Receptor Class A Domains Protein 1; Neuropilin (NRP) And Tolloid (TLL)-Like 1; BTCL1; Neuropilin And Tolloid-Like Protein 1; BCTL1;

Function

Involved in the development and/or maintenance of neuronal circuitry. Accessory subunit of the neuronal N-methyl-D-aspartate receptor (NMDAR) critical for maintaining the abundance of GRIN2A-containing NMDARs in the postsynaptic density. Regulates long-term NMDA receptor-dependent synaptic plasticity and cognition, at least in the context of spatial learning and memory (By similarity).

Biological Process

Memory Source: UniProtKB
Positive regulation of excitatory postsynaptic potential Source: Ensembl
Receptor localization to synapse Source: Ensembl
Regulation of kainate selective glutamate receptor activity Source: SynGO
Regulation of long-term neuronal synaptic plasticity Source: UniProtKB
Visual learning Source: UniProtKB

Cellular Location

Isoform 2:
Plasma membrane
Cell membrane
postsynaptic density membrane
Note: Component of the postsynaptic density (PSD) of excitatory synapses.By similarity
Isoform 3:
Plasma membrane
Cell membrane
Isoform 1:
Secreted

Topology

Extracellular: 23-344
Helical: 345-365
Cytoplasmic: 366-533

References

Greene, S. M., Klein, P. R., Alcala, G. A., Bustamante, I., Bordas, B., Johnson, A., ... & Gould, G. G. (2023). Aging to 24 months increased C57BL/6J mouse social sniffing and hippocampal Neto1 levels, and impaired female spatial learning. Behavioural Processes, 211, 104929.

Vinnakota, R., Dhingra, S., Kumari, J., Ansari, M. Y., Shukla, E., Nerkar, M. D., & Kumar, J. (2021). Role of Neto1 extracellular domain in modulation of kainate receptors. International Journal of Biological Macromolecules, 192, 525-536.

Xu, Y., Wang, W., Chen, J., Mao, H., Liu, Y., Gu, S., ... & Shi, W. (2020). High neuropilin and tolloid‐like 1 expression associated with metastasis and poor survival in epithelial ovarian cancer via regulation of actin cytoskeleton. Journal of Cellular and Molecular Medicine, 24(16), 9114-9124.

Jack, A., Hamad, M. I., Gonda, S., Gralla, S., Pahl, S., Hollmann, M., & Wahle, P. (2019). Development of cortical pyramidal cell and interneuronal dendrites: a role for kainate receptor subunits and NETO1. Molecular neurobiology, 56, 4960-4979.

Gould, G. G., Brady, A., Edwards, M. T., Garbarino, V. R., Sanchez, A., & Cody, J. D. (2019). Neuropilin and Tolloid‐Like 1 (Neto1) Deficiency Impairs, but CX614 Promotes Cognitive Flexibility. The FASEB Journal, 33(S1), 501-12.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Associated Products

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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