NETO1

This gene encodes a transmembrane protein containing two extracellular CUB domains followed by a low-density lipoprotein class A (LDLa) domain. This protein is thought to play a critical role in spatial learning and memory by regulating the function of synaptic N-methyl-D-aspartic acid receptor complexes in the hippocampus. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2017]
Full Name
Neuropilin And Tolloid Like 1
Function
Involved in the development and/or maintenance of neuronal circuitry. Accessory subunit of the neuronal N-methyl-D-aspartate receptor (NMDAR) critical for maintaining the abundance of GRIN2A-containing NMDARs in the postsynaptic density. Regulates long-term NMDA receptor-dependent synaptic plasticity and cognition, at least in the context of spatial learning and memory (By similarity).
Biological Process
Memory Source: UniProtKB
Positive regulation of excitatory postsynaptic potential Source: Ensembl
Receptor localization to synapse Source: Ensembl
Regulation of kainate selective glutamate receptor activity Source: SynGO
Regulation of long-term neuronal synaptic plasticity Source: UniProtKB
Visual learning Source: UniProtKB
Cellular Location
Isoform 2:
Plasma membrane
Cell membrane
postsynaptic density membrane
Note: Component of the postsynaptic density (PSD) of excitatory synapses.By similarity
Isoform 3:
Plasma membrane
Cell membrane
Isoform 1:
Secreted
Topology
Extracellular: 23-344
Helical: 345-365
Cytoplasmic: 366-533
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Anti-NETO1 antibodies

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Mouse Anti-NETO1 Recombinant Antibody (A1328) (CBMAB-AP5058LY)

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Target: NETO1
Host: Mouse
Antibody Isotype: IgM
Specificity: Human, Mouse
Clone: A1328
Application*: ICC, IHC, WB
Datasheet SDS

Mouse Anti-NETO1 Recombinant Antibody (CBWJN-0707) (CBMAB-N2005-WJ)

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Target: NETO1
Host: Mouse
Antibody Isotype: IgM
Specificity: Mouse
Clone: CBWJN-0707
Application*: WB, IC
Datasheet SDS

Mouse Anti-NETO1 Recombinant Antibody (CBWJN-0543) (CBMAB-N2003-WJ)

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Target: NETO1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJN-0543
Application*: E, IH
Datasheet SDS

Mouse Anti-NETO1 Recombinant Antibody (9A9E4) (CBMAB-N2002-WJ)

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Target: NETO1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 9A9E4
Application*: E
Datasheet SDS

Mouse Anti-NETO1 Recombinant Antibody (CBWJN-0978) (CBMAB-N0267-WJ)

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Target: NETO1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJN-0978
Application*: IH
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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