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NETO1

This gene encodes a transmembrane protein containing two extracellular CUB domains followed by a low-density lipoprotein class A (LDLa) domain. This protein is thought to play a critical role in spatial learning and memory by regulating the function of synaptic N-methyl-D-aspartic acid receptor complexes in the hippocampus. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2017]

Full Name

Neuropilin And Tolloid Like 1

Function

Involved in the development and/or maintenance of neuronal circuitry. Accessory subunit of the neuronal N-methyl-D-aspartate receptor (NMDAR) critical for maintaining the abundance of GRIN2A-containing NMDARs in the postsynaptic density. Regulates long-term NMDA receptor-dependent synaptic plasticity and cognition, at least in the context of spatial learning and memory (By similarity).

Biological Process

Memory Source: UniProtKB
Positive regulation of excitatory postsynaptic potential Source: Ensembl
Receptor localization to synapse Source: Ensembl
Regulation of kainate selective glutamate receptor activity Source: SynGO
Regulation of long-term neuronal synaptic plasticity Source: UniProtKB
Visual learning Source: UniProtKB

Cellular Location

Isoform 2:
Plasma membrane
Cell membrane
postsynaptic density membrane
Note: Component of the postsynaptic density (PSD) of excitatory synapses.By similarity
Isoform 3:
Plasma membrane
Cell membrane
Isoform 1:
Secreted

Topology

Extracellular: 23-344
Helical: 345-365
Cytoplasmic: 366-533

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Anti-NETO1 antibodies

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Human Recombinant NETO1 protein, His Tag (V2LY-0526-LY5748)

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Target: NETO1

Expressed Host: HEK293 Cells

Sequence: Amino Acid: 1-344

Tag: His Tag

Mouse Anti-NETO1 Recombinant Antibody (A1328) (CBMAB-AP5058LY)

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Target: NETO1

Host: Mouse

Antibody Isotype: IgM

Specificity: Human, Mouse

Clone: A1328

Application*: ICC, IHC, WB

Mouse Anti-NETO1 Recombinant Antibody (CBWJN-0707) (CBMAB-N2005-WJ)

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Target: NETO1

Host: Mouse

Antibody Isotype: IgM

Specificity: Mouse

Clone: CBWJN-0707

Application*: WB, IC

Mouse Anti-NETO1 Recombinant Antibody (CBWJN-0543) (CBMAB-N2003-WJ)

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Target: NETO1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBWJN-0543

Application*: E, IH

Mouse Anti-NETO1 Recombinant Antibody (9A9E4) (CBMAB-N2002-WJ)

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Target: NETO1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 9A9E4

Application*: E

Mouse Anti-NETO1 Recombinant Antibody (CBWJN-0978) (CBMAB-N0267-WJ)

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Target: NETO1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBWJN-0978

Application*: IH

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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