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Mouse Anti-NETO1 Recombinant Antibody (CBWJN-0978) (CBMAB-N0267-WJ)

This product is a Mouse antibody that recognizes NETO1. The antibody CBWJN-0978 can be used for immunoassay techniques such as: IHC.
See all NETO1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBWJN-0978
Antibody Isotype
IgG1
Application
IHC

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Buffer
PBS, Trehalose
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Neuropilin And Tolloid Like 1
Introduction
This gene encodes a transmembrane protein containing two extracellular CUB domains followed by a low-density lipoprotein class A (LDLa) domain. This protein is thought to play a critical role in spatial learning and memory by regulating the function of synaptic N-methyl-D-aspartic acid receptor complexes in the hippocampus. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2017]
Entrez Gene ID
81832
UniProt ID
Q8TDF5
Alternative Names
Neuropilin And Tolloid Like 1; Brain-Specific Transmembrane Protein Containing 2 CUB And 1 LDL-Receptor Class A Domains Protein 1; Neuropilin (NRP) And Tolloid (TLL)-Like 1; BTCL1; Neuropilin And Tolloid-Like Protein 1; BCTL1;
Function
Involved in the development and/or maintenance of neuronal circuitry. Accessory subunit of the neuronal N-methyl-D-aspartate receptor (NMDAR) critical for maintaining the abundance of GRIN2A-containing NMDARs in the postsynaptic density. Regulates long-term NMDA receptor-dependent synaptic plasticity and cognition, at least in the context of spatial learning and memory (By similarity).
Biological Process
Memory Source: UniProtKB
Positive regulation of excitatory postsynaptic potential Source: Ensembl
Receptor localization to synapse Source: Ensembl
Regulation of kainate selective glutamate receptor activity Source: SynGO
Regulation of long-term neuronal synaptic plasticity Source: UniProtKB
Visual learning Source: UniProtKB
Cellular Location
Isoform 2:
Plasma membrane
Cell membrane
postsynaptic density membrane
Note: Component of the postsynaptic density (PSD) of excitatory synapses.By similarity
Isoform 3:
Plasma membrane
Cell membrane
Isoform 1:
Secreted
Topology
Extracellular: 23-344
Helical: 345-365
Cytoplasmic: 366-533
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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