Mouse Anti-NETO1 Recombinant Antibody (CBWJN-0707) (CBMAB-N2005-WJ)

Name: Mouse Anti-NETO1 Recombinant Antibody (CBWJN-0707)
SKU: CBMAB-N2005-WJ
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBWJN-0707

Application

WB, ICC

Specificity

Mouse

Antibody Isotype

IgM

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Neuropilin And Tolloid Like 1

Introduction

This gene encodes a transmembrane protein containing two extracellular CUB domains followed by a low-density lipoprotein class A (LDLa) domain. This protein is thought to play a critical role in spatial learning and memory by regulating the function of synaptic N-methyl-D-aspartic acid receptor complexes in the hippocampus. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2017]

Entrez Gene ID

246317

UniProt ID

Q8R4I7

Alternative Names

Neuropilin And Tolloid Like 1; Brain-Specific Transmembrane Protein Containing 2 CUB And 1 LDL-Receptor Class A Domains Protein 1; Neuropilin (NRP) And Tolloid (TLL)-Like 1; BTCL1; Neuropilin And Tolloid-Like Protein 1; BCTL1;

Function

Involved in the development and/or maintenance of neuronal circuitry. Accessory subunit of the neuronal N-methyl-D-aspartate receptor (NMDAR) critical for maintaining the abundance of GRIN2A-containing NMDARs in the postsynaptic density. Regulates long-term NMDA receptor-dependent synaptic plasticity and cognition, at least in the context of spatial learning and memory (By similarity).

Biological Process

Memory Source: UniProtKB
Positive regulation of excitatory postsynaptic potential Source: Ensembl
Receptor localization to synapse Source: Ensembl
Regulation of kainate selective glutamate receptor activity Source: SynGO
Regulation of long-term neuronal synaptic plasticity Source: UniProtKB
Visual learning Source: UniProtKB

Cellular Location

Isoform 2:
Plasma membrane
Cell membrane
postsynaptic density membrane
Note: Component of the postsynaptic density (PSD) of excitatory synapses.By similarity
Isoform 3:
Plasma membrane
Cell membrane
Isoform 1:
Secreted

Topology

Extracellular: 23-344
Helical: 345-365
Cytoplasmic: 366-533

Greene, S. M., Klein, P. R., Alcala, G. A., Bustamante, I., Bordas, B., Johnson, A., ... & Gould, G. G. (2023). Aging to 24 months increased C57BL/6J mouse social sniffing and hippocampal Neto1 levels, and impaired female spatial learning. Behavioural Processes, 211, 104929.

Vinnakota, R., Dhingra, S., Kumari, J., Ansari, M. Y., Shukla, E., Nerkar, M. D., & Kumar, J. (2021). Role of Neto1 extracellular domain in modulation of kainate receptors. International Journal of Biological Macromolecules, 192, 525-536.

Xu, Y., Wang, W., Chen, J., Mao, H., Liu, Y., Gu, S., ... & Shi, W. (2020). High neuropilin and tolloid‐like 1 expression associated with metastasis and poor survival in epithelial ovarian cancer via regulation of actin cytoskeleton. Journal of Cellular and Molecular Medicine, 24(16), 9114-9124.

Jack, A., Hamad, M. I., Gonda, S., Gralla, S., Pahl, S., Hollmann, M., & Wahle, P. (2019). Development of cortical pyramidal cell and interneuronal dendrites: a role for kainate receptor subunits and NETO1. Molecular neurobiology, 56, 4960-4979.

Gould, G. G., Brady, A., Edwards, M. T., Garbarino, V. R., Sanchez, A., & Cody, J. D. (2019). Neuropilin and Tolloid‐Like 1 (Neto1) Deficiency Impairs, but CX614 Promotes Cognitive Flexibility. The FASEB Journal, 33(S1), 501-12.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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