Mouse Anti-NMT2 Recombinant Antibody (1H7) (CBMAB-N2827-WJ)

Name: Mouse Anti-NMT2 Recombinant Antibody (1H7)
SKU: CBMAB-N2827-WJ
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

1H7

Application

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.3, 1% BSA, 50% glycerol

Preservative

0.02% sodium azide

Concentration

0.42 mg/mL

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

N-myristoyltransferase 2

Introduction

This gene encodes one of two N-myristoyltransferase proteins. N-terminal myristoylation is a lipid modification that is involved in regulating the function and localization of signaling proteins. The encoded protein catalyzes the addition of a myristoyl group to the N-terminal glycine residue of many signaling proteins, including the human immunodeficiency virus type 1 (HIV-1) proteins, Gag and Nef. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]

Entrez Gene ID

9397

UniProt ID

O60551

Alternative Names

N-Myristoyltransferase 2; EC 2.3.1.97; Myristoyl-CoA:Protein N-Myristoyltransferase 2; Peptide N-Myristoyltransferase 2; Type II N-Myristoyltransferase; NMT 2;

Function

Adds a myristoyl group to the N-terminal glycine residue of certain cellular and viral proteins (PubMed:25255805, PubMed:9506952).
Also able to mediate N-terminal lysine myristoylation of proteins: catalyzes myristoylation of ARF6 on both 'Gly-2' and 'Lys-3' (PubMed:32103017).
Lysine myristoylation is required to maintain ARF6 on membranes during the GTPase cycle (PubMed:32103017).

Biological Process

Intracellular transport of virusTAS:Reactome
N-terminal peptidyl-glycine N-myristoylationManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of rhodopsin mediated signaling pathwayTAS:Reactome

Cellular Location

Cytoplasm
Membrane

Tomita, Y., Anzai, F., Misaka, T., Ogawara, R., Ichimura, S., Wada, K., ... & Takeishi, Y. (2023). Targeting N-myristoylation through NMT2 prevents cardiac hypertrophy and heart failure. Basic to Translational Science, 8(10), 1263-1282.

Gamma, J., Iyer, A., Yap, M., Zak, Z., Vincent, K., Ekstrom, C., ... & Berthiaume, L. G. (2021). Validation of NMT1 and NMT2 As Novel Drug Targets in Adult Acute Myeloid Leukemia: Rationale for N-Myristoyltransferase Inhibition with Pclx-001 for Clinical Trials. Blood, 138(Supplement 1), 4344-4344.

Kosciuk, T., Price, I. R., Zhang, X., Zhu, C., Johnson, K. N., Zhang, S., ... & Lin, H. (2020). NMT1 and NMT2 are lysine myristoyltransferases regulating the ARF6 GTPase cycle. Nature communications, 11(1), 1067.

Kosciuk, T., & Lin, H. (2020). N-myristoyltransferase as a glycine and lysine myristoyltransferase in cancer, immunity, and infections. ACS chemical biology, 15(7), 1747-1758.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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