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Rabbit Anti-NMT2 Recombinant Antibody (CBWJN-1454) (CBMAB-N2833-WJ)

This product is a Rabbit antibody that recognizes NMT2. The antibody CBWJN-1454 can be used for immunoassay techniques such as: WB, IHC-P, FC, ICC.
See all NMT2 antibodies

Summary

Host Animal
Rabbit
Specificity
Mouse, Rat, Human
Clone
CBWJN-1454
Antibody Isotype
IgG
Application
WB, IHC-P, FC, ICC

Basic Information

Specificity
Mouse, Rat, Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
N-myristoyltransferase 2
Introduction
This gene encodes one of two N-myristoyltransferase proteins. N-terminal myristoylation is a lipid modification that is involved in regulating the function and localization of signaling proteins. The encoded protein catalyzes the addition of a myristoyl group to the N-terminal glycine residue of many signaling proteins, including the human immunodeficiency virus type 1 (HIV-1) proteins, Gag and Nef. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]
Entrez Gene ID
Human9397
Mouse18108
Rat291318
UniProt ID
HumanO60551
MouseO70311
RatF1M110
Alternative Names
N-Myristoyltransferase 2; EC 2.3.1.97; Myristoyl-CoA:Protein N-Myristoyltransferase 2; Peptide N-Myristoyltransferase 2; Type II N-Myristoyltransferase; NMT 2;
Function
Adds a myristoyl group to the N-terminal glycine residue of certain cellular and viral proteins (PubMed:25255805, PubMed:9506952).
Also able to mediate N-terminal lysine myristoylation of proteins: catalyzes myristoylation of ARF6 on both 'Gly-2' and 'Lys-3' (PubMed:32103017).
Lysine myristoylation is required to maintain ARF6 on membranes during the GTPase cycle (PubMed:32103017).
Biological Process
Intracellular transport of virusTAS:Reactome
N-terminal peptidyl-glycine N-myristoylationManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of rhodopsin mediated signaling pathwayTAS:Reactome
Cellular Location
Cytoplasm
Membrane
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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