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Mouse Anti-NMT2 Recombinant Antibody (2E12-4B5) (CBMAB-A6030-LY)

The product is antibody recognizes NMT2. The antibody 2E12-4B5 immunoassay techniques such as: WB, ELISA.
See all NMT2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
2E12-4B5
Antibody Isotype
IgG1, κ
Application
WB, ELISA

Basic Information

Immunogen
NMT2 (AAH06376, 1 a.a. ~ 498 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
N-myristoyltransferase 2
Introduction
N-myristoyltransferase (NMT) catalyzes the reaction of N-terminal myristoylation of many signaling proteins. It transfers myristic acid from myristoyl coenzyme A to the amino group of a protein's N-terminal glycine residue. Biochemical evidence indicates the presence of several distinct NMTs, varying in apparent molecular weight and /or subcellular distribution. The predicted 498-amino acid of human NMT2 protein shares 77% and 96% sequence identity with human NMT1 and mouse Nmt2 comprise two distinct families of N-myristoyltransferases. [provided by RefSeq]
Entrez Gene ID
9397
UniProt ID
O60551
Function
Adds a myristoyl group to the N-terminal glycine residue of certain cellular and viral proteins (PubMed:25255805, PubMed:9506952).
Also able to mediate N-terminal lysine myristoylation of proteins: catalyzes myristoylation of ARF6 on both 'Gly-2' and 'Lys-3' (PubMed:32103017).
Lysine myristoylation is required to maintain ARF6 on membranes during the GTPase cycle (PubMed:32103017).
Biological Process
Intracellular transport of virusTAS:Reactome
N-terminal peptidyl-glycine N-myristoylationManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of rhodopsin mediated signaling pathwayTAS:Reactome
Cellular Location
Cytoplasm
Membrane
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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