Mouse Anti-NRBP1 Recombinant Antibody (4F2) (CBMAB-N3545-WJ)

Name: Mouse Anti-NRBP1 Recombinant Antibody (4F2)
SKU: CBMAB-N3545-WJ
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

4F2

Application

FC, IP, WB

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.3, 1% BSA, 50% glycerol

Preservative

0.02% sodium azide

Concentration

1.23 mg/mL

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Nuclear Receptor Binding Protein 1

Introduction

May play a role in subcellular trafficking between the endoplasmic reticulum and Golgi apparatus through interactions with the Rho-type GTPases. Binding to the NS3 protein of dengue virus type 2 appears to subvert this activity into the alteration of the intracellular membrane structure associated with flaviviral replication.

Entrez Gene ID

29959

UniProt ID

Q9UHY1

Alternative Names

Nuclear Receptor Binding Protein 1; BCON3; NRBP; Myeloid Leukemia Factor 1 Adaptor Molecule; Multiple Domain Putative Nuclear Protein; Nuclear Receptor Binding Protein; Nuclear Receptor-Binding Protein; MUDPNP; MADM;

Function

Biological Process

Endoplasmic reticulum to Golgi vesicle-mediated transportManual Assertion Based On ExperimentIDA:UniProtKB
Intracellular signal transductionManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Cytoplasm, cell cortex
Endomembrane system
Cell projection, lamellipodium
Colocalizes with activated RAC3 to endomembranes and at the cell periphery in lamellipodia.

Zhang, Q., Fang, H., & Zhu, Z. (2023). NRBP1 modulates uric acid transporter ABCG2 expression by activating the Wnt/β-catenin pathway in HK-2 cells. Nefrología (English Edition), 43(2), 204-212.

Yang, X., Cruz, M. I., Nguyen, E. V., Huang, C., Schittenhelm, R. B., Luu, J., ... & Daly, R. J. (2023). The pseudokinase NRBP1 activates Rac1/Cdc42 via P-Rex1 to drive oncogenic signalling in triple-negative breast cancer. Oncogene, 42(11), 833-847.

Mushtaq, Z., Aavula, K., Lasser, D. A., Kieweg, I. D., Lion, L. M., Kins, S., & Pielage, J. (2022). Madm/NRBP1 mediates synaptic maintenance and neurodegeneration-induced presynaptic homeostatic potentiation. Cell Reports, 41(9).

Yao, W., Cao, Q., Luo, S., He, L., Yang, C., Chen, J., ... & Zhang, J. C. (2022). Microglial ERK-NRBP1-CREB-BDNF signaling in sustained antidepressant actions of (R)-ketamine. Molecular psychiatry, 27(3), 1618-1629.

Du, L., Zhang, L., & Sun, F. (2022). Puerarin inhibits the progression of bladder cancer by regulating circ_0020394/miR-328-3p/NRBP1 axis. Cancer Biotherapy & Radiopharmaceuticals, 37(6), 435-450.

Ren, X., Cheng, J., Zhu, M., Chen, X., Jiang, M., Hu, X., & Lu, Y. (2022). Circular RNA circ_0062019 exerts oncogenic properties in prostate cancer via mediating miR‐1253/NRBP1 axis. Andrologia, 54(3), e14343.

Qin, L., Sun, X., Zhou, F., & Liu, C. (2021). CircLRP6 contributes to prostate cancer growth and metastasis by binding to miR-330-5p to up-regulate NRBP1. World Journal of Surgical Oncology, 19(1), 1-14.

Yasukawa, T., Tsutsui, A., Tomomori-Sato, C., Sato, S., Saraf, A., Washburn, M. P., ... & Aso, T. (2020). NRBP1-containing CRL2/CRL4A regulates amyloid β production by targeting BRI2 and BRI3 for degradation. Cell Reports, 30(10), 3478-3491.

Hwang, J., Haque, M. A., Suzuki, H., Ten Dijke, P., & Kato, M. (2020). THG-1 suppresses SALL4 degradation to induce stemness genes and tumorsphere formation through antagonizing NRBP1 in squamous cell carcinoma cells. Biochemical and biophysical research communications, 523(2), 307-314.

Wu, Q., Zhou, X., Li, P., Wang, W., Wang, J., Tan, M., ... & Qiu, J. (2019). High NRBP1 expression promotes proliferation and correlates with poor prognosis in bladder cancer. Journal of Cancer, 10(18), 4270.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Antibody Pairs

NRBP1 Matched Antibody Pair (819) (CAT#: APMAB-819LY)

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Isotype control

For research use only. Not intended for any clinical use.

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