Mouse Anti-OLIG2 Recombinant Antibody (CBXO-0548) (CBMAB-O0080-CQ)

Name: Mouse Anti-OLIG2 Recombinant Antibody (CBXO-0548)
SKU: CBMAB-O0080-CQ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBXO-0548

Application

IHC-Fr, IHC-P

Specificity

Human

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Oligodendrocyte Transcription Factor 2

Introduction

This gene encodes a basic helix-loop-helix transcription factor which is expressed in oligodendroglial tumors of the brain. The protein is an essential regulator of ventral neuroectodermal progenitor cell fate. The gene is involved in a chromosomal translocation t(14;21)(q11.2;q22) associated with T-cell acute lymphoblastic leukemia. Its chromosomal location is within a region of chromosome 21 which has been suggested to play a role in learning deficits associated with Down syndrome.

Entrez Gene ID

10215

UniProt ID

Q13516

Alternative Names

Oligodendrocyte Transcription Factor 2; Oligodendrocyte-Specific BHLH Transcription Factor 2; Basic Domain, Helix-Loop-Helix Protein, Class B, 1; Oligodendrocyte Lineage Transcription Factor 2; Human Protein Kinase C-Binding Protein RACK17; Class E Basic Helix-Loop-Helix Protein 19; Class B Basic Helix-Loop-Helix Protein 1; Protein Kinase C Binding Protein 2

Function

Required for oligodendrocyte and motor neuron specification in the spinal cord, as well as for the development of somatic motor neurons in the hindbrain. Functions together with ZNF488 to promote oligodendrocyte differentiation. Cooperates with OLIG1 to establish the pMN domain of the embryonic neural tube. Antagonist of V2 interneuron and of NKX2-2-induced V3 interneuron development.

Biological Process

MyelinationIEA:Ensembl
Negative regulation of neuron differentiationIEA:Ensembl
Negative regulation of transcription by RNA polymerase IIIEA:Ensembl
Neuron differentiationManual Assertion Based On ExperimentIBA:GO_Central
Neuron fate commitmentIEA:Ensembl
Positive regulation of oligodendrocyte differentiationIEA:Ensembl
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Spinal cord motor neuron differentiationIEA:Ensembl
Spinal cord oligodendrocyte cell fate specificationIEA:Ensembl
Thalamus developmentIEA:Ensembl

Cellular Location

Nucleus
Cytoplasm
The NLS contained in the bHLH domain could be masked in the native form and translocation to the nucleus could be mediated by interaction either with class E bHLH partner protein or with NKX2-2.

Involvement in disease

A chromosomal aberration involving OLIG2 may be a cause of a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(14;21)(q11.2;q22) with TCRA.

Fang, L. P., Liu, Q., Meyer, E., Welle, A., Huang, W., Scheller, A., ... & Bai, X. (2023). A subset of OPCs do not express Olig2 during development which can be increased in the adult by brain injuries and complex motor learning. Glia, 71(2), 415-430.

Xu, J., Zhao, J., Wang, R., Zhang, Y., Shen, L., Xiao, Q., ... & Deng, W. (2022). Shh and Olig2 sequentially regulate oligodendrocyte differentiation from hiPSCs for the treatment of ischemic stroke. Theranostics, 12(7), 3131.

Lee, J. E., Ahn, S., Jeong, H., An, S., Myung, C. H., Lee, J. A., ... & Hwang, J. S. (2021). Olig2 regulates p53-mediated apoptosis, migration and invasion of melanoma cells. Scientific reports, 11(1), 7778.

Sock, E., & Wegner, M. (2021). Using the lineage determinants Olig2 and Sox10 to explore transcriptional regulation of oligodendrocyte development. Developmental neurobiology, 81(7), 892-901.

Wei, H., Dong, X., You, Y., Hai, B., Duran, R. C. D., Wu, X., ... & Wu, J. Q. (2021). OLIG2 regulates lncRNAs and its own expression during oligodendrocyte lineage formation. BMC biology, 19(1), 132.

Wang, H., Xu, L., Lai, C., Hou, K., Chen, J., Guo, Y., ... & Chen, G. (2021). Region-specific distribution of Olig2-expressing astrocytes in adult mouse brain and spinal cord. Molecular brain, 14, 1-14.

Komatsu, H., Takeuchi, H., Kikuchi, Y., Ono, C., Yu, Z., Iizuka, K., ... & Tomita, H. (2020). Ethnicity-dependent effects of schizophrenia risk variants of the OLIG2 gene on OLIG2 transcription and white matter integrity. Schizophrenia Bulletin, 46(6), 1619-1628.

Bouchart, C., Trépant, A. L., Hein, M., Van Gestel, D., & Demetter, P. (2020). Prognostic impact of glioblastoma stem cell markers OLIG2 and CCND2. Cancer Medicine, 9(3), 1069-1078.

Wedel, M., Fröb, F., Elsesser, O., Wittmann, M. T., Lie, D. C., Reis, A., & Wegner, M. (2020). Transcription factor Tcf4 is the preferred heterodimerization partner for Olig2 in oligodendrocytes and required for differentiation. Nucleic acids research, 48(9), 4839-4857.

Xu, R., Brawner, A. T., Li, S., Liu, J. J., Kim, H., Xue, H., ... & Jiang, P. (2019). OLIG2 drives abnormal neurodevelopmental phenotypes in human iPSC-based organoid and chimeric mouse models of down syndrome. Cell stem cell, 24(6), 908-926.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Antibody Pairs

OLIG2 Matched Antibody Pair (831) (CAT#: APMAB-831LY)

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Isotype control

For research use only. Not intended for any clinical use.

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