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Mouse Anti-PACSIN3 Recombinant Antibody (2A3) (CBMAB-P0634-YC)

Provided herein is a Mouse monoclonal antibody against Human Protein Kinase C And Casein Kinase Substrate In Neurons 3. The antibody can be used for immunoassay techniques, such as FC, WB.
See all PACSIN3 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Dog, Rat, Monkey
Clone
2A3
Antibody Isotype
IgG1
Application
FC, WB

Basic Information

Specificity
Human, Dog, Rat, Monkey
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
PBS, pH 7.3, containing 1% BSA, 50% glycerol and 0.02% sodium azide
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
protein kinase C and casein kinase substrate in neurons 3
Introduction
PACSIN3 is a member of the protein kinase C and casein kinase substrate in neurons family. The encoded protein is involved in linking the actin cytoskeleton with vesicle formation.
Entrez Gene ID
Human29763
Dog475984
Rat311187
Monkey713919
UniProt ID
HumanQ9UKS6
DogF1Q433
RatQ5I2Z0
MonkeyG7NDG4
Alternative Names
Protein Kinase C And Casein Kinase Substrate In Neurons 3; SH3 Domain-Containing Protein 6511; Syndapin III; Protein Kinase C And Casein Kinase Substrate In Neurons Protein 3; SDPIII;
Function
Plays a role in endocytosis and regulates internalization of plasma membrane proteins. Overexpression impairs internalization of SLC2A1/GLUT1 and TRPV4 and increases the levels of SLC2A1/GLUT1 and TRPV4 at the cell membrane. Inhibits the TRPV4 calcium channel activity (By similarity).
Biological Process
Cytoskeleton organizationManual Assertion Based On ExperimentIBA:GO_Central
EndocytosisIEA:UniProtKB-KW
Negative regulation of calcium ion transportISS:UniProtKB
Negative regulation of endocytosisISS:UniProtKB
Plasma membrane tubulationManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of membrane protein ectodomain proteolysisManual Assertion Based On ExperimentIMP:BHF-UCL
Regulation of endocytosisManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Cytoplasm
Cell membrane
Detected at the inner aspect of the plasma membrane in myotubes.
PTM
Phosphorylated by casein kinase 2 (CK2) and protein kinase C (PKC).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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