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PACSIN3

PACSIN3 is a member of the protein kinase C and casein kinase substrate in neurons family. The encoded protein is involved in linking the actin cytoskeleton with vesicle formation.

Full Name

protein kinase C and casein kinase substrate in neurons 3

Function

Plays a role in endocytosis and regulates internalization of plasma membrane proteins. Overexpression impairs internalization of SLC2A1/GLUT1 and TRPV4 and increases the levels of SLC2A1/GLUT1 and TRPV4 at the cell membrane. Inhibits the TRPV4 calcium channel activity (By similarity).

Biological Process

Cytoskeleton organizationManual Assertion Based On ExperimentIBA:GO_Central
EndocytosisIEA:UniProtKB-KW
Negative regulation of calcium ion transportISS:UniProtKB
Negative regulation of endocytosisISS:UniProtKB
Plasma membrane tubulationManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of membrane protein ectodomain proteolysisManual Assertion Based On ExperimentIMP:BHF-UCL
Regulation of endocytosisManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Cytoplasm
Cell membrane
Detected at the inner aspect of the plasma membrane in myotubes.

PTM

Phosphorylated by casein kinase 2 (CK2) and protein kinase C (PKC).

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Anti-PACSIN3 antibodies

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Mouse Anti-PACSIN3 Recombinant Antibody (4F8) (CBMAB-P0637-YC)

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Target: PACSIN3

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 4F8

Application*: WB, F, IH, P

Mouse Anti-PACSIN3 Recombinant Antibody (2D7) (CBMAB-P0636-YC)

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Target: PACSIN3

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human, Dog, Rat, Monkey

Clone: 2D7

Application*: F, WB

Mouse Anti-PACSIN3 Recombinant Antibody (2A6) (CBMAB-P0635-YC)

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Target: PACSIN3

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human, Dog, Rat, Monkey

Clone: 2A6

Application*: F, WB

Mouse Anti-PACSIN3 Recombinant Antibody (2A3) (CBMAB-P0634-YC)

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Target: PACSIN3

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Dog, Rat, Monkey

Clone: 2A3

Application*: F, WB

Mouse Anti-PACSIN3 Recombinant Antibody (CBXS-4026) (CBMAB-S1287-CQ)

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Target: PACSIN3

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBXS-4026

Application*: F, WB

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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