PACSIN3

PACSIN3 is a member of the protein kinase C and casein kinase substrate in neurons family. The encoded protein is involved in linking the actin cytoskeleton with vesicle formation.
Full Name
protein kinase C and casein kinase substrate in neurons 3
Function
Plays a role in endocytosis and regulates internalization of plasma membrane proteins. Overexpression impairs internalization of SLC2A1/GLUT1 and TRPV4 and increases the levels of SLC2A1/GLUT1 and TRPV4 at the cell membrane. Inhibits the TRPV4 calcium channel activity (By similarity).
Biological Process
Cytoskeleton organizationManual Assertion Based On ExperimentIBA:GO_Central
EndocytosisIEA:UniProtKB-KW
Negative regulation of calcium ion transportISS:UniProtKB
Negative regulation of endocytosisISS:UniProtKB
Plasma membrane tubulationManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of membrane protein ectodomain proteolysisManual Assertion Based On ExperimentIMP:BHF-UCL
Regulation of endocytosisManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Cytoplasm
Cell membrane
Detected at the inner aspect of the plasma membrane in myotubes.
PTM
Phosphorylated by casein kinase 2 (CK2) and protein kinase C (PKC).
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Anti-PACSIN3 antibodies

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Mouse Anti-PACSIN3 Recombinant Antibody (4F8) (CBMAB-P0637-YC)

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Target: PACSIN3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 4F8
Application*: WB, F, IH, P
Datasheet SDS

Mouse Anti-PACSIN3 Recombinant Antibody (2D7) (CBMAB-P0636-YC)

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Target: PACSIN3
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Dog, Rat, Monkey
Clone: 2D7
Application*: F, WB
Datasheet SDS

Mouse Anti-PACSIN3 Recombinant Antibody (2A6) (CBMAB-P0635-YC)

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Target: PACSIN3
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Dog, Rat, Monkey
Clone: 2A6
Application*: F, WB
Datasheet SDS

Mouse Anti-PACSIN3 Recombinant Antibody (2A3) (CBMAB-P0634-YC)

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Target: PACSIN3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Dog, Rat, Monkey
Clone: 2A3
Application*: F, WB
Datasheet SDS

Mouse Anti-PACSIN3 Recombinant Antibody (CBXS-4026) (CBMAB-S1287-CQ)

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Target: PACSIN3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-4026
Application*: F, WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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