Mouse Anti-PACSIN3 Recombinant Antibody (4F8) (CBMAB-P0637-YC)

Name: Mouse Anti-PACSIN3 Recombinant Antibody (4F8)
SKU: CBMAB-P0637-YC
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

4F8

Application

WB, FC, IHC, IHC-P

Immunogen

Full length human recombinant protein of human PACSIN3 (NP_057307) produced in HEK293T cell

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

protein kinase C and casein kinase substrate in neurons 3

Introduction

PACSIN3 is a member of the protein kinase C and casein kinase substrate in neurons family. The encoded protein is involved in linking the actin cytoskeleton with vesicle formation.

Entrez Gene ID

29763

UniProt ID

Q9UKS6

Alternative Names

Protein Kinase C And Casein Kinase Substrate In Neurons 3; SH3 Domain-Containing Protein 6511; Syndapin III; Protein Kinase C And Casein Kinase Substrate In Neurons Protein 3; SDPIII;

Function

Plays a role in endocytosis and regulates internalization of plasma membrane proteins. Overexpression impairs internalization of SLC2A1/GLUT1 and TRPV4 and increases the levels of SLC2A1/GLUT1 and TRPV4 at the cell membrane. Inhibits the TRPV4 calcium channel activity (By similarity).

Biological Process

Cytoskeleton organizationManual Assertion Based On ExperimentIBA:GO_Central
EndocytosisIEA:UniProtKB-KW
Negative regulation of calcium ion transportISS:UniProtKB
Negative regulation of endocytosisISS:UniProtKB
Plasma membrane tubulationManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of membrane protein ectodomain proteolysisManual Assertion Based On ExperimentIMP:BHF-UCL
Regulation of endocytosisManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Cytoplasm
Cell membrane
Detected at the inner aspect of the plasma membrane in myotubes.

PTM

Phosphorylated by casein kinase 2 (CK2) and protein kinase C (PKC).

Han, G. H., Shim, J. E., Yun, H., Kim, J., Kim, J. H., & Cho, H. (2022). RNA sequencing and bioinformatics analysis revealed PACSIN3 as a potential novel biomarker for platinum resistance in epithelial ovarian cancer. The journal of gene medicine, 24(11), e3452.

Han, G. H., Cho, H., Yun, H., & Kim, J. H. (2022). PACSIN3 is a novel biomarker for platinum resistance BRCA mutated platinum resistance epithelial ovarian cancer.

Milewska, M., Domoradzki, T., Majewska, A., Błaszczyk, M., Gajewska, M., Hulanicka, M., & Grzelkowska-Kowalczyk, K. (2020). Interleukin-6 affects pacsin3, ephrinA4 expression and cytoskeletal proteins in differentiating primary skeletal myoblasts through transcriptional and post-transcriptional mechanisms. Cell and tissue research, 380, 155-172.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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