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Mouse Anti-PASD1 Recombinant Antibody (1C2) (CBMAB-A6334-LY)

The product is antibody recognizes PASD1. The antibody 1C2 immunoassay techniques such as: WB, ELISA.
See all PASD1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1C2
Antibody Isotype
IgG2a, κ
Application
WB, ELISA

Basic Information

Immunogen
PASD1 (NP_775764, 1 a.a. ~ 100 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
PAS Domain Containing Repressor 1
Entrez Gene ID
139135
UniProt ID
Q8IV76
Function
Functions as a suppressor of the biological clock that drives the daily circadian rhythms of cells throughout the body (PubMed:25936801).
Acts as a nuclear repressor of the CLOCK-ARNTL/BMAL1 heterodimer-mediated transcriptional activation of the core clock components (PubMed:25936801).
Inhibits circadian clock function in cancer cells, when overexpressed (PubMed:25936801).
Biological Process
Circadian regulation of gene expressionManual Assertion Based On ExperimentIBA:GO_Central
Negative regulation of circadian rhythmManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Isoform 1
Nucleus
Associates preferentially at the periphery of the nucleus with heterochromatin (PubMed:25936801).
Isoform 2
Nucleus
Associates preferentially at the periphery of the nucleus with heterochromatin (PubMed:25936801).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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