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Mouse Anti-PASD1 Recombinant Antibody (1C8) (CBMAB-P0837-YC)

Provided herein is a Mouse monoclonal antibody against Human PAS Domain Containing Repressor 1. The antibody can be used for immunoassay techniques, such as ELISA, WB.
See all PASD1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1C8
Antibody Isotype
IgG2b, κ
Application
ELISA, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
PBS, pH 7.2
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
PAS Domain Containing Repressor 1
Introduction
PASD1 is a protein that is thought to function as a transcription factor. The protein is a cancer-associated antigen that can stimulate autologous T-cell responses, and it is therefore considered to be a potential immunotherapeutic target for the treatment of various hematopoietic malignancies, including diffuse large B-cell lymphoma.
Entrez Gene ID
139135
UniProt ID
Q8IV76
Alternative Names
PAS Domain Containing Repressor 1; Cancer/Testis Antigen 63; PAS Domain Containing 1; CT63; PAS Domain-Containing Protein 1; Circadian Clock Protein PASD1; OX-TES-1; OXTES1; CT64;
Function
Functions as a suppressor of the biological clock that drives the daily circadian rhythms of cells throughout the body (PubMed:25936801).
Acts as a nuclear repressor of the CLOCK-ARNTL/BMAL1 heterodimer-mediated transcriptional activation of the core clock components (PubMed:25936801).
Inhibits circadian clock function in cancer cells, when overexpressed (PubMed:25936801).
Biological Process
Circadian regulation of gene expressionManual Assertion Based On ExperimentIBA:GO_Central
Negative regulation of circadian rhythmManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Isoform 1
Nucleus
Associates preferentially at the periphery of the nucleus with heterochromatin (PubMed:25936801).
Isoform 2
Nucleus
Associates preferentially at the periphery of the nucleus with heterochromatin (PubMed:25936801).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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