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PASD1

PASD1 is thought to function as a transcription factor. The protein is a cancer-associated antigen that can stimulate autologous T-cell responses, and it is therefore considered to be a potential immunotherapeutic target for the treatment of various hematopoietic malignancies, including diffuse large B-cell lymphoma.

Full Name

PAS Domain Containing Repressor 1

Function

Functions as a suppressor of the biological clock that drives the daily circadian rhythms of cells throughout the body (PubMed:25936801).
Acts as a nuclear repressor of the CLOCK-ARNTL/BMAL1 heterodimer-mediated transcriptional activation of the core clock components (PubMed:25936801).
Inhibits circadian clock function in cancer cells, when overexpressed (PubMed:25936801).

Biological Process

Circadian regulation of gene expressionManual Assertion Based On ExperimentIBA:GO_Central
Negative regulation of circadian rhythmManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Isoform 1
Nucleus
Associates preferentially at the periphery of the nucleus with heterochromatin (PubMed:25936801).
Isoform 2
Nucleus
Associates preferentially at the periphery of the nucleus with heterochromatin (PubMed:25936801).

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Anti-PASD1 antibodies

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Mouse Anti-PASD1 Recombinant Antibody (1F5) (CBMAB-A6336-LY)

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Target: PASD1

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: 1F5

Application*: WB, E

Mouse Anti-PASD1 Recombinant Antibody (1C2) (CBMAB-A6334-LY)

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Target: PASD1

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 1C2

Application*: WB, E

Recombinant Mouse Anti-PASD1 Recombinant Antibody (2ALCC136) (CBMAB-XB0908-YC)

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Target: PASD1

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: 2ALCC136

Application*: IH, IF, WB

Mouse Anti-PASD1 Recombinant Antibody (3C1) (CBMAB-P0839-YC)

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Target: PASD1

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 3C1

Application*: E, IC, IF, WB

Mouse Anti-PASD1 Recombinant Antibody (2ALCC128) (CBMAB-P0838-YC)

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Target: PASD1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 2ALCC128

Application*: WB, IH

Mouse Anti-PASD1 Recombinant Antibody (1C8) (CBMAB-P0837-YC)

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Target: PASD1

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: 1C8

Application*: E, WB

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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