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PASD1

PASD1 is thought to function as a transcription factor. The protein is a cancer-associated antigen that can stimulate autologous T-cell responses, and it is therefore considered to be a potential immunotherapeutic target for the treatment of various hematopoietic malignancies, including diffuse large B-cell lymphoma.
Full Name
PAS Domain Containing Repressor 1
Function
Functions as a suppressor of the biological clock that drives the daily circadian rhythms of cells throughout the body (PubMed:25936801).
Acts as a nuclear repressor of the CLOCK-ARNTL/BMAL1 heterodimer-mediated transcriptional activation of the core clock components (PubMed:25936801).
Inhibits circadian clock function in cancer cells, when overexpressed (PubMed:25936801).
Biological Process
Circadian regulation of gene expressionManual Assertion Based On ExperimentIBA:GO_Central
Negative regulation of circadian rhythmManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Isoform 1
Nucleus
Associates preferentially at the periphery of the nucleus with heterochromatin (PubMed:25936801).
Isoform 2
Nucleus
Associates preferentially at the periphery of the nucleus with heterochromatin (PubMed:25936801).
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Anti-PASD1 antibodies

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Mouse Anti-PASD1 Recombinant Antibody (1F5) (CBMAB-A6336-LY)

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Target: PASD1
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 1F5
Application*: WB, E
Datasheet SDS

Mouse Anti-PASD1 Recombinant Antibody (1C2) (CBMAB-A6334-LY)

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Target: PASD1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 1C2
Application*: WB, E
Datasheet SDS

Recombinant Mouse Anti-PASD1 Recombinant Antibody (2ALCC136) (CBMAB-XB0908-YC)

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Target: PASD1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 2ALCC136
Application*: IH, IF, WB
Datasheet SDS

Mouse Anti-PASD1 Recombinant Antibody (3C1) (CBMAB-P0839-YC)

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Target: PASD1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 3C1
Application*: E, IC, IF, WB
Datasheet SDS

Mouse Anti-PASD1 Recombinant Antibody (2ALCC128) (CBMAB-P0838-YC)

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Target: PASD1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2ALCC128
Application*: WB, IH
Datasheet SDS

Mouse Anti-PASD1 Recombinant Antibody (1C8) (CBMAB-P0837-YC)

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Target: PASD1
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 1C8
Application*: E, WB
Datasheet SDS
More Infomation
Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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