PASD1

PASD1 is thought to function as a transcription factor. The protein is a cancer-associated antigen that can stimulate autologous T-cell responses, and it is therefore considered to be a potential immunotherapeutic target for the treatment of various hematopoietic malignancies, including diffuse large B-cell lymphoma.

Full Name

PAS Domain Containing Repressor 1

Function

Functions as a suppressor of the biological clock that drives the daily circadian rhythms of cells throughout the body (PubMed:25936801).
Acts as a nuclear repressor of the CLOCK-ARNTL/BMAL1 heterodimer-mediated transcriptional activation of the core clock components (PubMed:25936801).
Inhibits circadian clock function in cancer cells, when overexpressed (PubMed:25936801).

Biological Process

Circadian regulation of gene expressionManual Assertion Based On ExperimentIBA:GO_Central
Negative regulation of circadian rhythmManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Isoform 1
Nucleus
Associates preferentially at the periphery of the nucleus with heterochromatin (PubMed:25936801).
Isoform 2
Nucleus
Associates preferentially at the periphery of the nucleus with heterochromatin (PubMed:25936801).

Anti-PASD1 antibodies

Mouse Anti-PASD1 Recombinant Antibody (1F5) (CBMAB-A6336-LY)

Datasheet

SDS

Target: PASD1

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: 1F5

Application*: WB, E

Mouse Anti-PASD1 Recombinant Antibody (1C2) (CBMAB-A6334-LY)

Datasheet

SDS

Target: PASD1

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 1C2

Application*: WB, E

Recombinant Mouse Anti-PASD1 Recombinant Antibody (2ALCC136) (CBMAB-XB0908-YC)

Datasheet

SDS

Target: PASD1

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: 2ALCC136

Application*: IH, IF, WB

Mouse Anti-PASD1 Recombinant Antibody (3C1) (CBMAB-P0839-YC)

Datasheet

SDS

Target: PASD1

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 3C1

Application*: E, IC, IF, WB

Mouse Anti-PASD1 Recombinant Antibody (2ALCC128) (CBMAB-P0838-YC)

Datasheet

SDS

Target: PASD1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 2ALCC128

Application*: WB, IH

Mouse Anti-PASD1 Recombinant Antibody (1C8) (CBMAB-P0837-YC)

Datasheet

SDS

Target: PASD1

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: 1C8

Application*: E, WB

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)