Mouse Anti-PASD1 Recombinant Antibody (2ALCC128) (CBMAB-P0838-YC)

Name: Mouse Anti-PASD1 Recombinant Antibody (2ALCC128)
SKU: CBMAB-P0838-YC
Rating: 5 (1 reviews)

See all PASD1 antibodies

Compare Online Inquiry

Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

2ALCC128

Application

WB, IHC

Immunogen

GST-PASD1 recombinant protein containing the 540-773 aas of PASD1, a region only present in PASD1b

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

PAS Domain Containing Repressor 1

Introduction

PASD1 is a protein that is thought to function as a transcription factor. The protein is a cancer-associated antigen that can stimulate autologous T-cell responses, and it is therefore considered to be a potential immunotherapeutic target for the treatment of various hematopoietic malignancies, including diffuse large B-cell lymphoma.

Entrez Gene ID

139135

UniProt ID

Q8IV76

Alternative Names

PAS Domain Containing Repressor 1; Cancer/Testis Antigen 63; PAS Domain Containing 1; CT63; PAS Domain-Containing Protein 1; Circadian Clock Protein PASD1; OX-TES-1; OXTES1; CT64;

Function

Functions as a suppressor of the biological clock that drives the daily circadian rhythms of cells throughout the body (PubMed:25936801).
Acts as a nuclear repressor of the CLOCK-ARNTL/BMAL1 heterodimer-mediated transcriptional activation of the core clock components (PubMed:25936801).
Inhibits circadian clock function in cancer cells, when overexpressed (PubMed:25936801).

Biological Process

Circadian regulation of gene expressionManual Assertion Based On ExperimentIBA:GO_Central
Negative regulation of circadian rhythmManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Isoform 1
Nucleus
Associates preferentially at the periphery of the nucleus with heterochromatin (PubMed:25936801).
Isoform 2
Nucleus
Associates preferentially at the periphery of the nucleus with heterochromatin (PubMed:25936801).

Sukor, N. F., Yahaya, A., Sagap, I., Jamal, R., & Johdi, N. A. (2022). Cancer testis antigen PASD1 expression and immunogenicity in human colorectal cancer and polyps. Turkish Journal of Biology, 46(5), 361-374.

Sukor, N. F. (2021). PASD1 Expression and CD4 T Cell Response In Colorectal Cancer And Polyps Patients At UKM Medical Centre (Doctoral dissertation, UKM Medical Molecular Biology Institute Universiti Kebangsaan Malaysia, Kuala Lumpur).

Soh, J. E., Abu, N., Sagap, I., Mazlan, L., Yahaya, A., Mustangin, M., ... & Jamal, R. (2019). Validation of immunogenic PASD1 peptides against HLA-A* 24: 02 colorectal cancer. Immunotherapy, 11(14), 1205-1219.

Li, R., Guo, M., & Song, L. (2019). PAS domain containing repressor 1 (PASD1) promotes glioma cell proliferation through inhibiting apoptosis in vitro. Medical Science Monitor: International Medical Journal of Experimental and Clinical Research, 25, 6955.

Ask a question We look forward to hearing from you.

0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Have you used Mouse Anti-PASD1 Recombinant Antibody (2ALCC128)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon

$30 eGift Card
Submit a review

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Related Products

Recombinant Mouse Anti-PASD1 Recombinant Antibody (2ALCC136) (CAT#: CBMAB-XB0908-YC)

Mouse Anti-PASD1 Recombinant Antibody (3C1) (CAT#: CBMAB-P0839-YC)

Mouse Anti-PASD1 Recombinant Antibody (1C2) (CAT#: CBMAB-A6334-LY)

Mouse Anti-PASD1 Recombinant Antibody (1F5) (CAT#: CBMAB-A6336-LY)

Mouse Anti-PASD1 Recombinant Antibody (1C8) (CAT#: CBMAB-P0837-YC)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Request bulk or custom quote Second antibody and isotype control

Contact us

Tel: (USA)
(UK)
Fax:

Global Locations

Email:

Online Inquiry