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Mouse Anti-PDE9A Recombinant Antibody (1E1) (CBMAB-P1232-YC)

Provided herein is a Mouse monoclonal antibody against Human Phosphodiesterase 9A. The antibody can be used for immunoassay techniques, such as ELISA, IHC-P, WB.
See all PDE9A antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1E1
Antibody Isotype
IgG2a, κ
Application
ELISA, IHC-P, WB

Basic Information

Immunogen
Recombinant protein
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
phosphodiesterase 9A
Introduction
PDE9A catalyzes the hydrolysis of cAMP and cGMP to their corresponding monophosphates. The encoded protein plays a role in signal transduction by regulating the intracellular concentration of these cyclic nucleotides. Multiple transcript variants encoding several different isoforms have been found for this gene.
Entrez Gene ID
5152
UniProt ID
O76083
Alternative Names
Phosphodiesterase 9A; High Affinity CGMP-Specific 3,5-Cyclic Phosphodiesterase 9A; CGMP-Specific 3,5-Cyclic Phosphodiesterase Type 9; Phosphodiesterase PDE9A21; EC 3.1.4.35; HSPDE9A2;
Function
Specifically hydrolyzes the second messenger cGMP, which is a key regulator of many important physiological processes. Highly specific: compared to other members of the cyclic nucleotide phosphodiesterase family, has the highest affinity and selectivity for cGMP (PubMed:9624146, PubMed:18757755, PubMed:21483814).
Specifically regulates natriuretic-peptide-dependent cGMP signaling in heart, acting as a regulator of cardiac hypertrophy in myocytes and muscle. Does not regulate nitric oxide-dependent cGMP in heart (PubMed:25799991).
Additional experiments are required to confirm whether its ability to hydrolyze natriuretic-peptide-dependent cGMP is specific to heart or is a general feature of the protein (Probable). In brain, involved in cognitive function, such as learning and long-term memory (By similarity).
Biological Process
cGMP catabolic processManual Assertion Based On ExperimentIDA:UniProtKB
cGMP metabolic processManual Assertion Based On ExperimentIDA:UniProtKB
cGMP-mediated signalingManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of cardiac muscle hypertrophyISS:UniProtKB
Signal transductionManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Isoform PDE9A1
Cell projection, ruffle membrane
Cytoplasm, perinuclear region
Golgi apparatus
Endoplasmic reticulum
Cell membrane, sarcolemma
Isoform PDE9A2
Cell projection, ruffle membrane
Cytoplasm, perinuclear region
Isoform PDE9A3
Cytoplasm
Endoplasmic reticulum
Isoform PDE9A17
Cytoplasm
Endoplasmic reticulum
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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