Human Recombinant PDE9A, Active protein, GST Tag (V2LY-0526-LY6046)
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Basic Information
Formulations & Storage [For reference only, actual COA shall prevail!]
Target
Specifically regulates natriuretic-peptide-dependent cGMP signaling in heart, acting as a regulator of cardiac hypertrophy in myocytes and muscle. Does not regulate nitric oxide-dependent cGMP in heart (PubMed:25799991).
Additional experiments are required to confirm whether its ability to hydrolyze natriuretic-peptide-dependent cGMP is specific to heart or is a general feature of the protein (Probable). In brain, involved in cognitive function, such as learning and long-term memory (By similarity).
cGMP metabolic processManual Assertion Based On ExperimentIDA:UniProtKB
cGMP-mediated signalingManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of cardiac muscle hypertrophyISS:UniProtKB
Signal transductionManual Assertion Based On ExperimentIBA:GO_Central
Cell projection, ruffle membrane
Cytoplasm, perinuclear region
Golgi apparatus
Endoplasmic reticulum
Cell membrane, sarcolemma
Isoform PDE9A2
Cell projection, ruffle membrane
Cytoplasm, perinuclear region
Isoform PDE9A3
Cytoplasm
Endoplasmic reticulum
Isoform PDE9A17
Cytoplasm
Endoplasmic reticulum
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Please try the standard protocols which include: protocols, troubleshooting and guide.
Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols
Alternative Versions
Human Recombinant PDE9A protein, GST Tag (CAT#: V2LY-0526-LY6047)
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Human Recombinant PDE9A protein, His Tag (CAT#: V2LY-0526-LY6048)
Custom Antibody Labeling
We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).
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