PDE9A

The protein encoded by this gene catalyzes the hydrolysis of cAMP and cGMP to their corresponding monophosphates. The encoded protein plays a role in signal transduction by regulating the intracellular concentration of these cyclic nucleotides. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq]

Full Name

phosphodiesterase 9A

Function

Specifically hydrolyzes the second messenger cGMP, which is a key regulator of many important physiological processes. Highly specific: compared to other members of the cyclic nucleotide phosphodiesterase family, has the highest affinity and selectivity for cGMP (PubMed:9624146, PubMed:18757755, PubMed:21483814).
Specifically regulates natriuretic-peptide-dependent cGMP signaling in heart, acting as a regulator of cardiac hypertrophy in myocytes and muscle. Does not regulate nitric oxide-dependent cGMP in heart (PubMed:25799991).
Additional experiments are required to confirm whether its ability to hydrolyze natriuretic-peptide-dependent cGMP is specific to heart or is a general feature of the protein (Probable). In brain, involved in cognitive function, such as learning and long-term memory (By similarity).

Biological Process

cGMP catabolic processManual Assertion Based On ExperimentIDA:UniProtKB
cGMP metabolic processManual Assertion Based On ExperimentIDA:UniProtKB
cGMP-mediated signalingManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of cardiac muscle hypertrophyISS:UniProtKB
Signal transductionManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Isoform PDE9A1
Cell projection, ruffle membrane
Cytoplasm, perinuclear region
Golgi apparatus
Endoplasmic reticulum
Cell membrane, sarcolemma
Isoform PDE9A2
Cell projection, ruffle membrane
Cytoplasm, perinuclear region
Isoform PDE9A3
Cytoplasm
Endoplasmic reticulum
Isoform PDE9A17
Cytoplasm
Endoplasmic reticulum