Mouse Anti-PDZD3 Recombinant Antibody (1F2) (CBMAB-A6555-LY)

Name: Mouse Anti-PDZD3 Recombinant Antibody (1F2)
SKU: CBMAB-A6555-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

1F2

Application

WB, ELISA

Immunogen

PDZD3 (AAH29042, 1 a.a. ~ 491 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Specificity

Human

Antibody Isotype

IgG1, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

PDZ Domain Containing 3

Introduction

Guanylyl cyclase C (GCC, or GUCY2C; MIM 601330) produces cGMP following the binding of either endogenous ligands or heat-stable enterotoxins secreted by E. coli and other enteric bacteria. Activation of GCC initiates a signaling cascade that leads to phosphorylation of the cystic fibrosis transmembrane conductance regulator (CFTR; MIM 602421), followed by a net efflux of ions and water into the intestinal lumen. IKEPP is a regulatory protein that associates with GCC and regulates the amount of cGMP produced following receptor stimulation (Scott et al., 2002 [PubMed 11950846]).[supplied by OMIM

Entrez Gene ID

79849

UniProt ID

Q86UT5

Alternative Names

FLJ22756; IKEPP; PDZK2

Function

Acts as a regulatory protein that associates with GUCY2C and negatively modulates its heat-stable enterotoxin-mediated activation (PubMed:11950846).
Stimulates SLC9A3 activity in the presence of elevated calcium ions (PubMed:19088451).

Biological Process

Ion transport1 PublicationNAS:UniProtKB
Negative regulation of cGMP-mediated signalingManual Assertion Based On ExperimentIDA:UniProtKB
Protein localization to plasma membraneManual Assertion Based On ExperimentIBA:GO_Central
Receptor guanylyl cyclase signaling pathway1 PublicationIC:UniProtKB
Response to toxic substanceManual Assertion Based On ExperimentTAS:UniProtKB
Water transport1 PublicationNAS:UniProtKB

Cellular Location

Cell membrane
Cytoplasm
Preferentially accumulates at the apical surface and ileal brush border of intestinal epithelial cells (PubMed:11950846, PubMed:19088451).

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Antibody Pairs

PDZD3 Matched Antibody Pair (860) (CAT#: APMAB-860LY)

Related Products

PDZD3 Matched Antibody Pair (860) (CAT#: APMAB-860LY)

Mouse Anti-PDZD3 Recombinant Antibody (2G1) (CAT#: CBMAB-P1389-YC)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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