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Mouse Anti-PDZD3 Recombinant Antibody (1F2) (CBMAB-A6555-LY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
1F2
Antibody Isotype
IgG1, κ
Application
WB, ELISA

Basic Information

Immunogen
PDZD3 (AAH29042, 1 a.a. ~ 491 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
PDZ Domain Containing 3
Introduction
Guanylyl cyclase C (GCC, or GUCY2C; MIM 601330) produces cGMP following the binding of either endogenous ligands or heat-stable enterotoxins secreted by E. coli and other enteric bacteria. Activation of GCC initiates a signaling cascade that leads to phosphorylation of the cystic fibrosis transmembrane conductance regulator (CFTR; MIM 602421), followed by a net efflux of ions and water into the intestinal lumen. IKEPP is a regulatory protein that associates with GCC and regulates the amount of cGMP produced following receptor stimulation (Scott et al., 2002 [PubMed 11950846]).[supplied by OMIM
Entrez Gene ID
79849
UniProt ID
Q86UT5
Alternative Names
FLJ22756; IKEPP; PDZK2
Function
Acts as a regulatory protein that associates with GUCY2C and negatively modulates its heat-stable enterotoxin-mediated activation (PubMed:11950846).
Stimulates SLC9A3 activity in the presence of elevated calcium ions (PubMed:19088451).
Biological Process
Ion transport1 PublicationNAS:UniProtKB
Negative regulation of cGMP-mediated signalingManual Assertion Based On ExperimentIDA:UniProtKB
Protein localization to plasma membraneManual Assertion Based On ExperimentIBA:GO_Central
Receptor guanylyl cyclase signaling pathway1 PublicationIC:UniProtKB
Response to toxic substanceManual Assertion Based On ExperimentTAS:UniProtKB
Water transport1 PublicationNAS:UniProtKB
Cellular Location
Cell membrane
Cytoplasm
Preferentially accumulates at the apical surface and ileal brush border of intestinal epithelial cells (PubMed:11950846, PubMed:19088451).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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