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Mouse Anti-PDZD3 Recombinant Antibody (2G1) (CBMAB-P1389-YC)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
2G1
Antibody Isotype
IgM, κ
Application
ELISA

Basic Information

Immunogen
PDZD3 (AAH29042, 1-491 aa) full length recombinant protein with GST tag. Immunogen sequence: MEKAADLQDT ASLTLKFKFN PKLGIDNPVL SLAEDHDPYD PWSLERPRFC LLSKEEGKSF GFHLQQELGR AGHVVCRVDP GTSAQRQGLQ EGDRILAVNN DVVEHEDYAV VVRRIRASSP RVLLTVLARH AHDVARAQLG EDAHLCPTLG PGVRPRLCHI VKDEGGFGFS VTHGNQGPFW LVLSTGGAAE RAGVPPGARL LEVNGLWQSG QQVTLLVAGP EVEEQCRQLG LPLAAPLAEG WALPTKPRCL HLEKGPQGFG FLLREEKGLD GRPGQFLWEV DPGLPAKKAG MQAGDRLVAV AGESVEGLGH EETVSRIQGQ GSCVSLTVVD PEADRFFSMV RLSPLLFLEN TEAPASPQGS SSASLVETED PSLEDTSVPS VPLGSRQCFL YPGPGGSYGF RLSCVASGPR LFISQVTPGG SAARAGLQVG DVILEVNGYP VGGQNDLERL QQLPEAEPPL CLKLAARSLR GLEAWIPPGA AEDWALASDL L
Specificity
Human
Antibody Isotype
IgM, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 1-491

Target

Full Name
PDZ Domain Containing 3
Introduction
Guanylyl cyclase C produces cGMP following the binding of either endogenous ligands or heat-stable enterotoxins secreted by E. coli and other enteric bacteria. Activation of GCC initiates a signaling cascade that leads to phosphorylation of the cystic fibrosis transmembrane conductance regulator, followed by a net efflux of ions and water into the intestinal lumen. IKEPP is a regulatory protein that associates with GCC and regulates the amount of cGMP produced following receptor stimulation.
Entrez Gene ID
79849
UniProt ID
Q86UT5
Alternative Names
PDZ Domain Containing 3; Natrium-Phosphate Cotransporter IIa C-Terminal-Associated Protein 2; Na/Pi Cotransporter C-Terminal-Associated Protein 2; Sodium-Hydrogen Exchanger Regulatory Factor 4; PDZ Domain-Containing Protein 2; PDZ Domain-Containing Protein 3; PDZ Domain Containing 2; NaPi-Cap2;
Function
Acts as a regulatory protein that associates with GUCY2C and negatively modulates its heat-stable enterotoxin-mediated activation (PubMed:11950846).
Stimulates SLC9A3 activity in the presence of elevated calcium ions (PubMed:19088451).
Biological Process
Ion transport1 PublicationNAS:UniProtKB
Negative regulation of cGMP-mediated signalingManual Assertion Based On ExperimentIDA:UniProtKB
Protein localization to plasma membraneManual Assertion Based On ExperimentIBA:GO_Central
Receptor guanylyl cyclase signaling pathway1 PublicationIC:UniProtKB
Response to toxic substanceManual Assertion Based On ExperimentTAS:UniProtKB
Water transport1 PublicationNAS:UniProtKB
Cellular Location
Cell membrane
Cytoplasm
Preferentially accumulates at the apical surface and ileal brush border of intestinal epithelial cells (PubMed:11950846, PubMed:19088451).
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For research use only. Not intended for any clinical use.

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