PDZD3

Guanylyl cyclase C (GCC, or GUCY2C; MIM 601330) produces cGMP following the binding of either endogenous ligands or heat-stable enterotoxins secreted by E. coli and other enteric bacteria. Activation of GCC initiates a signaling cascade that leads to phosphorylation of the cystic fibrosis transmembrane conductance regulator (CFTR; MIM 602421), followed by a net efflux of ions and water into the intestinal lumen. IKEPP is a regulatory protein that associates with GCC and regulates the amount of cGMP produced following receptor stimulation (Scott et al., 2002 [PubMed 11950846]).[supplied by OMIM, Mar 2008]

PDZ Domain Containing 3

Acts as a regulatory protein that associates with GUCY2C and negatively modulates its heat-stable enterotoxin-mediated activation (PubMed:11950846).
Stimulates SLC9A3 activity in the presence of elevated calcium ions (PubMed:19088451).

Ion transport1 PublicationNAS:UniProtKB
Negative regulation of cGMP-mediated signalingManual Assertion Based On ExperimentIDA:UniProtKB
Protein localization to plasma membraneManual Assertion Based On ExperimentIBA:GO_Central
Receptor guanylyl cyclase signaling pathway1 PublicationIC:UniProtKB
Response to toxic substanceManual Assertion Based On ExperimentTAS:UniProtKB
Water transport1 PublicationNAS:UniProtKB

Cell membrane
Cytoplasm
Preferentially accumulates at the apical surface and ileal brush border of intestinal epithelial cells (PubMed:11950846, PubMed:19088451).