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PDZD3 Matched Antibody Pair (860) (APMAB-860LY)


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Specifications

ApplIcation
Sandwich ELISA
Specificity
Human
Capture Antibody
Rabbit anti-PDZD3 polyclonal antibody, 100 ug
Detection Antibody
Anti-PDZD3 Mouse polyclonal antibody, 20 ug
Dilutions
10 ng/ml-100 ng/ml
Format
Liquid
Storage
Aliquot and store at -20°Cor -80°C. Avoid freeze-thaw cycles.
Introduction
Guanylyl cyclase C (GCC, or GUCY2C; MIM 601330) produces cGMP following the binding of either endogenous ligands or heat-stable enterotoxins secreted by E. coli and other enteric bacteria. Activation of GCC initiates a signaling cascade that leads to phosphorylation of the cystic fibrosis transmembrane conductance regulator (CFTR; MIM 602421), followed by a net efflux of ions and water into the intestinal lumen. IKEPP is a regulatory protein that associates with GCC and regulates the amount of cGMP produced following receptor stimulation (Scott et al., 2002 [PubMed 11950846]).[supplied by OMIM, Mar 2008]
Alternative Names
PDZ Domain Containing 3; Natrium-Phosphate Cotransporter IIa C-Terminal-Associated Protein 2; Na/Pi Cotransporter C-Terminal-Associated Protein 2; Sodium-Hydrogen Exchanger Regulatory Factor 4; PDZ Domain-Containing Protein 2; PDZ Domain-Containing Protein 3; PDZ Domain Containing 2; NaPi-Cap2;
Entrez Gene ID
79849
UniProt ID
Q86UT5
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For research use only. Not intended for any clinical use.

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