Mouse Anti-PGK1 Recombinant Antibody (1086CT10.2.1) (CBMAB-P1579-YC)

Name: Mouse Anti-PGK1 Recombinant Antibody (1086CT10.2.1)
SKU: CBMAB-P1579-YC
Rating: 5 (1 reviews)

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Datasheet

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Basic Information

Host Animal

Mouse

Clone

1086CT10.2.1

Application

ELISA, WB

Immunogen

A KLH conjugated synthetic peptide between 1-417 amino acids from human

Specificity

Human

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

PBS with 0.09% sodium azide

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

phosphoglycerate kinase 1

Introduction

PGK1 is a glycolytic enzyme that catalyzes the conversion of 1,3-diphosphoglycerate to 3-phosphoglycerate. The encoded protein may also act as a cofactor for polymerase alpha. Additionally, this protein is secreted by tumor cells where it participates in angiogenesis by functioning to reduce disulfide bonds in the serine protease, plasmin, which consequently leads to the release of the tumor blood vessel inhibitor angiostatin. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Deficiency of the enzyme is associated with a wide range of clinical phenotypes hemolytic anemia and neurological impairment. Pseudogenes of this gene have been defined on chromosomes 19, 21 and the X chromosome.

Entrez Gene ID

5230

UniProt ID

P00558

Alternative Names

Phosphoglycerate Kinase 1; Cell Migration-Inducing Gene 10 Protein; Primer Recognition Protein 2; EC 2.7.2.3; PRP 2; PGKA; Epididymis Secretory Sperm Binding Protein Li 68p; HEL-S-68p; MIG10;

Function

Catalyzes one of the two ATP producing reactions in the glycolytic pathway via the reversible conversion of 1,3-diphosphoglycerate to 3-phosphoglycerate (PubMed:30323285, PubMed:7391028).
In addition to its role as a glycolytic enzyme, it seems that PGK-1 acts as a polymerase alpha cofactor protein (primer recognition protein) (PubMed:2324090).
May play a role in sperm motility (PubMed:26677959).

Biological Process

Cellular response to hypoxiaManual Assertion Based On ExperimentIDA:CAFA
Epithelial cell differentiationManual Assertion Based On ExperimentIEP:UniProtKB
GluconeogenesisManual Assertion Based On ExperimentIBA:GO_Central
Glycolytic processManual Assertion Based On ExperimentIMP:CAFA
Negative regulation of angiogenesisManual Assertion Based On ExperimentIMP:CAFA
PhosphorylationISS:UniProtKB
Plasminogen activationManual Assertion Based On ExperimentIMP:CAFA

Cellular Location

Cytoplasm

Involvement in disease

Phosphoglycerate kinase 1 deficiency (PGK1D):
A condition with a highly variable clinical phenotype that includes hemolytic anemia, rhabdomyolysis, myopathy and neurologic involvement. Patients can express one or more of these manifestations.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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