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Mouse Anti-PGK1 Recombinant Antibody (2H4) (CBMAB-A6599-LY)

The product is antibody recognizes PGK1. The antibody 2H4 immunoassay techniques such as: WB, ELISA.
See all PGK1 antibodies
Published Data
Fig.1 Representative western blotting analysis of PGK1 expression in breast tissues.
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Fig.2 Immunohistochemical staining of PGK1 in breast tissues.
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Summary

Host Animal
Mouse
Specificity
Human
Clone
2H4
Antibody Isotype
IgG2a, κ
Application
WB, ELISA

Basic Information

Immunogen
PGK1 (NP_000282, 321 a.a. ~ 417 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
phosphoglycerate kinase 1
Introduction
The protein encoded by this gene is a glycolytic enzyme that catalyzes the conversion of 1,3-diphosphoglycerate to 3-phosphoglycerate. The encoded protein may also act as a cofactor for polymerase alpha. This gene lies on the X-chromosome, while a related pseudogene also has been found on the X-chromosome and another on chromosome 19. [provided by RefSeq]
Entrez Gene ID
5230
UniProt ID
P00558
Alternative Names
MGC117307; MGC142128; MGC8947; MIG10; PGKA
Function
Catalyzes one of the two ATP producing reactions in the glycolytic pathway via the reversible conversion of 1,3-diphosphoglycerate to 3-phosphoglycerate (PubMed:30323285, PubMed:7391028).
In addition to its role as a glycolytic enzyme, it seems that PGK-1 acts as a polymerase alpha cofactor protein (primer recognition protein) (PubMed:2324090).
May play a role in sperm motility (PubMed:26677959).
Biological Process
Cellular response to hypoxiaManual Assertion Based On ExperimentIDA:CAFA
Epithelial cell differentiationManual Assertion Based On ExperimentIEP:UniProtKB
GluconeogenesisManual Assertion Based On ExperimentIBA:GO_Central
Glycolytic processManual Assertion Based On ExperimentIMP:CAFA
Negative regulation of angiogenesisManual Assertion Based On ExperimentIMP:CAFA
PhosphorylationISS:UniProtKB
Plasminogen activationManual Assertion Based On ExperimentIMP:CAFA
Cellular Location
Cytoplasm
Involvement in disease
Phosphoglycerate kinase 1 deficiency (PGK1D):
A condition with a highly variable clinical phenotype that includes hemolytic anemia, rhabdomyolysis, myopathy and neurologic involvement. Patients can express one or more of these manifestations.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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