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Mouse Anti-PGRMC1 Recombinant Antibody (1C10D11) (CBMAB-P1626-YC)

Provided herein is a Mouse monoclonal antibody against Human Progesterone Receptor Membrane Component 1. The antibody can be used for immunoassay techniques, such as ELISA, WB, IHC.
See all PGRMC1 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
1C10D11
Antibody Isotype
IgG1
Application
ELISA, WB, IHC

Basic Information

Specificity
Human, Mouse, Rat
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Progesterone Receptor Membrane Component 1
Introduction
PGRMC1 is a putative membrane-associated progesterone steroid receptor. The protein is expressed predominantly in the liver and kidney.
Entrez Gene ID
Human10857
Mouse53328
Rat291948
UniProt ID
HumanO00264
MouseO55022
RatP70580
Alternative Names
HPR6.6; MPR
Function
Component of a progesterone-binding protein complex (PubMed:28396637).
Binds progesterone (PubMed:25675345).
Has many reported cellular functions (heme homeostasis, interaction with CYPs). Required for the maintenance of uterine histoarchitecture and normal female reproductive lifespan (By similarity).
Intracellular heme chaperone. Regulates heme synthesis via interactions with FECH and acts as a heme donor for at least some hemoproteins (PubMed:27599036).
Biological Process
Associative learningIEA:Ensembl
Axon guidanceIEA:Ensembl
Heme biosynthetic processManual Assertion Based On ExperimentIDA:UniProtKB
MemoryIEA:Ensembl
Modification of synaptic structureIEA:Ensembl
Negative regulation of synapse organizationIEA:Ensembl
Positive regulation of protein localization to plasma membraneIEA:Ensembl
Cellular Location
Microsome membrane
Smooth endoplasmic reticulum membrane
Mitochondrion outer membrane
Topology
Lumenal: 1-24
Helical: 25-43
Cytoplasmic: 44-195
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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